EC number:1.1.1.14

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.14
Description:L-iditol 2-dehydrogenase.
Alternative Name: Sorbitol dehydrogenase.
Polyol dehydrogenase.
Glucitol dehydrogenase.
Prosite: PDOC00058;
PDB:
PDBScop
Cath: 3.40.50.720; 3.90.180.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.14
BRENDA Enzyme Link: BRENDA 1.1.1.14
KEGG Enzyme Link: KEGG1.1.1.14
BioCyc Enzyme Link: BioCyc 1.1.1.14
ExPASy Enzyme Link: ExPASy1.1.1.14
EC2PDB Enzyme Link: EC2PDB 1.1.1.14
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.14
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.14
IntEnz Enzyme Link: IntEnz 1.1.1.14
MEDLINE Enzyme Link: MEDLINE 1.1.1.14

EC number:1.1.1.14

MSA:

1.1.1.14;
Phylogenetic Tree:

1.1.1.14;
Uniprot:
M-CSA:
RHEA:10160 L-iditol + NAD(+) = H(+) + L-sorbopyranose + NADH
RULE(radius=1) ([*:1]-[CH;+0:2](-[*:3])-[*:4].[*:5]-[OH;+0:6]).[*:7]-[n+;H0:8]1:[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:1>>[*:7]-[N;H0;+0:8]1-[CH;+0:9]=[CH;+0:10]-[CH2;+0:11]-[C;H0;+0:12](-[*:13])=[CH;+0:14]-1.[*:5]-[O;H0;+0:6]-[C;H0;+0:2](-[*:1])(-[*:3])-[*:4]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
X-ray crystal structure and small-angle X-ray scattering of sheep liver sorbitol dehydrogenase.Yennawar H, Møller M, Gillilan R, Yennawar N2011 May21543846
Steady-state kinetic properties of sorbitol dehydrogenase from chicken liver.Karacaoğlan V, Ozer I2005 Feb15649778
X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase.Pauly TA, Ekstrom JL, Beebe DA, Chrunyk B, Cunningham D, Griffor M, Kamath A, Lee SE, Madura R, Mcguire D, Subashi T, Wasilko D, Watts P, Mylari BL, Oates PJ, Adams PD, Rath VL2003 Sep12962626