Enzyme

Download
EC Tree
     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.141
Description:15-hydroxyprostaglandin dehydrogenase (NAD(+)).
Alternative Name: 15-hydroxyprostaglandin dehydrogenase.
Prosite: PDOC00060;
PDB:
PDBScop
Cath: 3.40.50.720;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.141
BRENDA Enzyme Link: BRENDA 1.1.1.141
KEGG Enzyme Link: KEGG1.1.1.141
BioCyc Enzyme Link: BioCyc 1.1.1.141
ExPASy Enzyme Link: ExPASy1.1.1.141
EC2PDB Enzyme Link: EC2PDB 1.1.1.141
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.141
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.141
IntEnz Enzyme Link: IntEnz 1.1.1.141
MEDLINE Enzyme Link: MEDLINE 1.1.1.141
MSA:

1.1.1.141;

Phylogenetic Tree:

1.1.1.141;

Uniprot:
M-CSA:
RHEA:11876 NAD(+) + prostaglandin E2 = 15-oxo-prostaglandin E2 + H(+) + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.Ensor CM, Tai HH1994 Sep 218086429
NAD+-dependent 15-hgydroxyprostaglandin dehydrogenase from porcine kidney. II. Kinetic studies.Kung-Chao DT, Tai HH1980 Jul 107190439
15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids.Wendell SG, Golin-Bisello F, Wenzel S, Sobol RW, Holguin F, Freeman BA2015 Feb 2725586183
Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta.Jarabak J, Braithwaite SS1976 Nov187123
[15-Hydroxyprostaglandin dehydrogenase from human placenta, II. Steady state kinetics and influence of prostaglandin F2alpha analogues (author's transl)].Rückrich MF, Wendel A, Schlegel W, Jackisch R, Jung A1975 Jun171213
Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2.Cho H, Huang L, Hamza A, Gao D, Zhan CG, Tai HH2006 Oct 116828555
NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions.Tai HH, Cho H, Tong M, Ding Y200616533162
Understanding human 15-hydroxyprostaglandin dehydrogenase binding with NAD+ and PGE2 by homology modeling, docking and molecular dynamics simulation.Hamza A, Cho H, Tai HH, Zhan CG2005 Jul 1515908215
Identification of dual cyclooxygenase-eicosanoid oxidoreductase inhibitors: NSAIDs that inhibit PG-LX reductase/LTB(4) dehydrogenase.Clish CB, Sun YP, Serhan CN2001 Nov 911688989