EC number:1.1.1.146
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.146 | ||
|---|---|---|---|
| Description: | 11-beta-hydroxysteroid dehydrogenase. | ||
| Alternative Name: |
Corticosteroid 11-beta-dehydrogenase. | ||
| Prosite: | PDOC00060; | ||
| PDB: |
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| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.146 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.146 |
| KEGG Enzyme Link: | KEGG1.1.1.146 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.146 |
| ExPASy Enzyme Link: | ExPASy1.1.1.146 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.146 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.146 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.146 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.146 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.146 |
EC number:1.1.1.146
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:11388 | an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Lumenal orientation and post-translational modifications of the liver microsomal 11 beta-hydroxysteroid dehydrogenase. | Ozols J | 1995 Feb 3 | 7836463 |
| The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors. | Yuan C, St Jean DJ Jr, Liu Q, Cai L, Li A, Han N, Moniz G, Askew B, Hungate RW, Johansson L, Tedenborg L, Pyring D, Williams M, Hale C, Chen M, Cupples R, Zhang J, Jordan S, Bartberger MD, Sun Y, Emery M, Wang M, Fotsch C | 2007 Nov 15 | 17919905 |
| At5g50600 encodes a member of the short-chain dehydrogenase reductase superfamily with 11beta- and 17beta-hydroxysteroid dehydrogenase activities associated with Arabidopsis thaliana seed oil bodies. | d'Andréa S, Canonge M, Beopoulos A, Jolivet P, Hartmann MA, Miquel M, Lepiniec L, Chardot T | 2007 Feb | 17074428 |
| Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors. | Sorensen B, Winn M, Rohde J, Shuai Q, Wang J, Fung S, Monzon K, Chiou W, Stolarik D, Imade H, Pan L, Deng X, Chovan L, Longenecker K, Judge R, Qin W, Brune M, Camp H, Frevert EU, Jacobson P, Link JT | 2007 Jan 15 | 17070044 |
| Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase. | Frick C, Atanasov AG, Arnold P, Ozols J, Odermatt A | 2004 Jul 23 | 15152005 |
| The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane. | Odermatt A, Arnold P, Stauffer A, Frey BM, Frey FJ | 1999 Oct 1 | 10497248 |