EC number:1.1.1.149
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.149 | ||
|---|---|---|---|
| Description: | 20-alpha-hydroxysteroid dehydrogenase. | ||
| Prosite: | PDOC00061; | ||
| PDB: |
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| Cath: | 3.20.20.10; 3.20.20.100; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.149 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.149 |
| KEGG Enzyme Link: | KEGG1.1.1.149 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.149 |
| ExPASy Enzyme Link: | ExPASy1.1.1.149 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.149 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.149 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.149 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.149 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.149 |
EC number:1.1.1.149
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:15857 | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NADP(+) = 17alpha-hydroxyprogesterone + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells. | Hara A, Matsuura K, Tamada Y, Sato K, Miyabe Y, Deyashiki Y, Ishida N | 1996 Jan 15 | 8573067 |
| Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site. | Strickler RC, Tobias B, Covey DF | 1981 Jan 10 | 6935192 |
| Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes. | Shikita M, Inano H, Tamaoki B | 1967 Jun | 4382486 |
| Characterization of a human 20alpha-hydroxysteroid dehydrogenase. | Zhang Y, Dufort I, Rheault P, Luu-The V | 2000 Oct | 11013348 |
| RHEA:15853 | 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells. | Hara A, Matsuura K, Tamada Y, Sato K, Miyabe Y, Deyashiki Y, Ishida N | 1996 Jan 15 | 8573067 |
| Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site. | Strickler RC, Tobias B, Covey DF | 1981 Jan 10 | 6935192 |
| Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes. | Shikita M, Inano H, Tamaoki B | 1967 Jun | 4382486 |
| Characterization of a human 20alpha-hydroxysteroid dehydrogenase. | Zhang Y, Dufort I, Rheault P, Luu-The V | 2000 Oct | 11013348 |