EC number:1.1.1.169
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.169 |
|---|---|
| Description: | 2-dehydropantoate 2-reductase. |
| Alternative Name: |
KPA reductase. Ketopantoic acid reductase. Ketopantoate reductase. |
| Cath: | 1.10.1040.10; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.169 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.169 |
| KEGG Enzyme Link: | KEGG1.1.1.169 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.169 |
| ExPASy Enzyme Link: | ExPASy1.1.1.169 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.169 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.169 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.169 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.169 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.169 |
EC number:1.1.1.169
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:16233 | (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium. | Frodyma ME, Downs D | 1998 Sep | 9721324 |
| Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity. | Ciulli A, Chirgadze DY, Smith AG, Blundell TL, Abell C | 2007 Mar 16 | 17229734 |
| The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound. | Lobley CM, Ciulli A, Whitney HM, Williams G, Smith AG, Abell C, Blundell TL | 2005 Jun 28 | 15966718 |
| Kinetic and mechanistic analysis of the E. coli panE-encoded ketopantoate reductase. | Zheng R, Blanchard JS | 2000 Apr 4 | 10736170 |