EC number:1.1.1.170
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.170 |
|---|---|
| Description: | (decarboxylating). |
| Alternative Name: |
Sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating). Sterol 4-alpha-carboxylic decarboxylase. 3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase. 3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating). 3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.170 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.170 |
| KEGG Enzyme Link: | KEGG1.1.1.170 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.170 |
| ExPASy Enzyme Link: | ExPASy1.1.1.170 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.170 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.170 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.170 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.170 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.170 |
EC number:1.1.1.170
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:33447 | 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[C;H0;+0:10](-[OH;+0:11])-[C;H0;+0:12](-[*:13])(-[*:14])-[CH;+0:15](-[*:16])-[OH;+0:17]>>[*:13]-[CH;+0:12](-[*:14])-[C;H0;+0:15](-[*:16])=[O;H0;+0:17].[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10]=[O;H0;+0:11] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. | Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P | 2013 Jul 1 | 23583456 |
| Interactions of the ergosterol biosynthetic pathway with other lipid pathways. | Veen M, Lang C | 2005 Nov | 16246076 |
| RHEA:34771 | a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid + CO2 + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[C;H0;+0:3](=[*:4])-[OH;+0:5])-[CH;+0:6](-[*:7])-[OH;+0:8].[*:9]-[n+;H0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[c;H0;+0:14](-[*:15]):[cH;+0:16]:1>>[*:1]-[CH2;+0:2]-[C;H0;+0:6](-[*:7])=[O;H0;+0:8].[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[CH;+0:12]-[CH2;+0:13]-[C;H0;+0:14](-[*:15])=[CH;+0:16]-1.[*:4]=[C;H0;+0:3]=[O;H0;+0:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. | Gachotte D, Barbuch R, Gaylor J, Nickel E, Bard M | 1998 Nov 10 | 9811880 |
| Mixed function oxidases in sterol metabolism. Source of reducing equivalents. | Brady DR, Crowder RD, Hayes WJ | 1980 Nov 25 | 7430141 |
| Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase. | Rahimtula AD, Gaylor JL | 1972 Jan 10 | 4401584 |
| NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets. | Caldas H, Herman GE | 2003 Nov 15 | 14506130 |
| RHEA:34775 | a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[C;H0;+0:3](=[*:4])-[OH;+0:5])-[CH;+0:6](-[*:7])-[OH;+0:8].[*:9]-[n+;H0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[c;H0;+0:14](-[*:15]):[cH;+0:16]:1>>[*:1]-[CH2;+0:2]-[C;H0;+0:6](-[*:7])=[O;H0;+0:8].[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[CH;+0:12]-[CH2;+0:13]-[C;H0;+0:14](-[*:15])=[CH;+0:16]-1.[*:4]=[C;H0;+0:3]=[O;H0;+0:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. | Gachotte D, Barbuch R, Gaylor J, Nickel E, Bard M | 1998 Nov 10 | 9811880 |
| Mixed function oxidases in sterol metabolism. Source of reducing equivalents. | Brady DR, Crowder RD, Hayes WJ | 1980 Nov 25 | 7430141 |
| Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase. | Rahimtula AD, Gaylor JL | 1972 Jan 10 | 4401584 |
| NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets. | Caldas H, Herman GE | 2003 Nov 15 | 14506130 |