EC number:1.1.1.176
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.176 |
|---|---|
| Description: | 12-alpha-hydroxysteroid dehydrogenase. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.176 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.176 |
| KEGG Enzyme Link: | KEGG1.1.1.176 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.176 |
| ExPASy Enzyme Link: | ExPASy1.1.1.176 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.176 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.176 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.176 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.176 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.176 |
EC number:1.1.1.176
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:14129 | cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Bile salt degradation by nonfermentative clostridia. | Mahony DE, Meier CE, Macdonald IA, Holdeman LV | 1977 Oct | 921266 |
| NAD-dependent 3alpha- and 12alpha-hydroxysteroid dehydrogenase activities from Eubacterium lentum ATCC no. 25559. | MacDonald IA, Mahony DE, Jellet JF, Meier CE | 1977 Dec 21 | 201289 |