EC number:1.1.1.181
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.181 |
|---|---|
| Description: | Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase. |
| Alternative Name: |
3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.181 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.181 |
| KEGG Enzyme Link: | KEGG1.1.1.181 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.181 |
| ExPASy Enzyme Link: | ExPASy1.1.1.181 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.181 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.181 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.181 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.181 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.181 |
EC number:1.1.1.181
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:11896 | 7alpha-hydroxycholesterol + NAD(+) = 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[CH2;+0:5]-[CH;+0:6](-[*:7])-[OH;+0:8].[*:9]-[n+;H0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[c;H0;+0:14](-[*:15]):[cH;+0:16]:1>>[*:1]-[CH2;+0:2]-[C;H0;+0:3](-[*:4])=[CH;+0:5]-[C;H0;+0:6](-[*:7])=[O;H0;+0:8].[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[CH;+0:12]-[CH2;+0:13]-[C;H0;+0:14](-[*:15])=[CH;+0:16]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis. | Schwarz M, Wright AC, Davis DL, Nazer H, Björkhem I, Russell DW | 2000 Nov | 11067870 |