EC number:1.1.1.189
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.189 | ||
|---|---|---|---|
| Description: | Prostaglandin-E(2) 9-reductase. | ||
| Alternative Name: |
Prostaglandin-E2 9-reductase. Prostaglandin-E(2) 9-oxoreductase. PGE(2) 9-oxoreductase. PGE(2) 9-ketoreductase. 9-ketoprostaglandin reductase. 9-keto-prostaglandin E(2) reductase. | ||
| Prosite: | PDOC00060; | ||
| PDB: |
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| Cath: | 3.20.20.10; 3.20.20.100; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.189 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.189 |
| KEGG Enzyme Link: | KEGG1.1.1.189 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.189 |
| ExPASy Enzyme Link: | ExPASy1.1.1.189 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.189 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.189 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.189 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.189 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.189 |
EC number:1.1.1.189
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:24508 | NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin E2 |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and assay of 9-hydroxyprostaglandin dehydrogenase from rat kidney. | Tai HH, Yuan B | 1982 | 7132747 |
| Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase. | Wermuth B | 1981 Feb 10 | 7005231 |
| Purification of prostaglandin E2-9-oxoreductase from human decidua vera. | Schlegel W, Krüger S, Korte K | 1984 Jun 4 | 6586494 |
| Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase. | Schieber A, Frank RW, Ghisla S | 1992 Jun 1 | 1597188 |