EC number:1.1.1.19
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.19 |
|---|---|
| Description: | Glucuronate reductase. |
| Alternative Name: |
TPN-L-gulonate dehydrogenase. NADP-L-gulonate dehydrogenase. L-glucuronate reductase. Glucuronate dehydrogenase. D-glucuronate reductase. D-glucuronate dehydrogenase. Aldehyde reductase II. Aldehyde reductase. |
| Cath: | 1.20.1090.10; 3.20.20.10; 3.20.20.100; 3.40.50.720; 3.90.180.10; 3.40.50.1970; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.19 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.19 |
| KEGG Enzyme Link: | KEGG1.1.1.19 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.19 |
| ExPASy Enzyme Link: | ExPASy1.1.1.19 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.19 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.19 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.19 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.19 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.19 |
| RHEA:14909 | L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[*:3].[*:4]-[OH;+0:5]).[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1.[*:4]-[O;H0;+0:5]-[CH;+0:2](-[*:1])-[*:3] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymes of mesoinositol catabolism in the yeast Schwanniomyces accidentalis. | SIVAK A, HOFFMANN-OSTENHOF O | 1961 Oct 28 | 13913518 |
| TPN-L-gluonate dehydrogenase. | YORK JL, GROLLMAN AP, BUBLITZ C | 1961 Feb 18 | 13787380 |
| In vivo role of aldehyde reductase. | Takahashi M, Miyata S, Fujii J, Inai Y, Ueyama S, Araki M, Soga T, Fujinawa R, Nishitani C, Ariki S, Shimizu T, Abe T, Ihara Y, Nishikimi M, Kozutsumi Y, Taniguchi N, Kuroki Y | 2012 Nov | 22820017 |
| Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis. | Gabbay KH, Bohren KM, Morello R, Bertin T, Liu J, Vogel P | 2010 Jun 18 | 20410296 |
| Purification and properties of NADPH-dependent aldehyde reductase from human liver. | Wermuth B, Münch JD, von Wartburg JP | 1977 Jun 10 | 16919 |