EC number:1.1.1.2
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
3D structure
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1C9W;
1LWI;
1AFS;
1RAL;
1M9H;
1HW6;
1A80;
1DLA;
1EKO;
1AH4;
1AH3;
1AH0;
1FRB;
5HA7;
4XZH;
3Q67;
3Q65;
1EF3;
6F8O;
6F84;
6F82;
6F81;
6F7R;
5OUK;
5OUJ;
5OU0;
4YU1;
4YS1;
4XZI;
4RPQ;
4QXI;
4QX4;
4QR6;
4QBX;
4Q7B;
4PUW;
4PUU;
4PRT;
4PRR;
4PR4;
4NKC;
4LBS;
4LBR;
4LB4;
4LB3;
4LAZ;
4LAU;
4JIR;
4IGS;
4GCA;
3V36;
3V35;
3U2C;
3T42;
3S3G;
3RX4;
3RX3;
3RX2;
3P2V;
3ONC;
3ONB;
3MC5;
3MB9;
3M64;
3M4H;
3M0I;
3LZ5;
3LZ3;
3LQL;
3LQG;
3LEP;
3LEN;
3LD5;
3LBO;
3GHU;
3GHT;
3GHS;
3GHR;
3G5E;
3DN5;
3BCJ;
2R24;
2PZN;
2PFH;
2PF8;
2PEV;
2PDY;
2PDX;
2PDW;
2PDU;
2PDQ;
2PDP;
2PDN;
2PDM;
2PDL;
2PDJ;
2PDI;
2PDH;
2PDG;
2PDF;
2PDC;
2PDB;
2PD9;
2PD5;
2NVD;
2NVC;
2J8T;
2ISF;
2IS7;
2IQD;
2IQ0;
2IPW;
2INZ;
2INE;
2IKJ;
2IKI;
2IKH;
2IKG;
2I17;
2I16;
2HVO;
2HVN;
2HV5;
2FZD;
2FZB;
2FZ9;
2FZ8;
2F2K;
2DV0;
2DUZ;
2DUX;
2AGT;
2ACU;
2ACS;
2ACR;
2ACQ;
1Z8A;
1Z89;
1Z3N;
1XGD;
1X98;
1X97;
1X96;
1US0;
1T41;
1T40;
1PWM;
1PWL;
1MAR;
1IEI;
1EL3;
1AZ2;
1AZ1;
1ADS;
1ABN;
6GXK;
6F78;
6F2U;
5JM5;
5HNU;
5HNT;
4ZFC;
4YVX;
4YVV;
4XVD;
4WDX;
4WDW;
4FAM;
4DBW;
4DBU;
4DBS;
1RY8;
1RY0;
4XVE;
4WRH;
4WDU;
4WDT;
4HMN;
4FAL;
4FA3;
4DZ5;
3UWE;
3UGR;
3UG8;
3UFY;
3R94;
3R8H;
3R8G;
3R7M;
3R6I;
3R58;
3R43;
2F38;
1ZQ5;
1XF0;
1S2C;
1S2A;
1S1R;
1S1P;
4XO7;
4XO6;
4L1X;
4L1W;
4JTR;
4JTQ;
4JQA;
4JQ4;
4JQ3;
4JQ2;
4JQ1;
2IPJ;
2HDJ;
1XJB;
1J96;
1IHI;
1PZ0;
1PYF;
1Q5M;
1Q13;
1MZR;
4YVP;
3NTY;
3GUG;
3C3U;
1MRQ;
1Z9A;
1YE6;
1YE4;
1SM9;
1R38;
1MI3;
1K8C;
1JEZ;
6M7K;
5Z6U;
5Z6T;
5Y7N;
5UXF;
5M2F;
5LIY;
5LIX;
5LIW;
5LIU;
5LIK;
4XZN;
4XZM;
4XZL;
4WEV;
4OTK;
4JII;
4JIH;
4IJR;
4IJC;
4ICC;
4I5X;
4H8N;
4H7C;
4GQG;
4GQ0;
4GIE;
4GAC;
4GAB;
4GA8;
4G5D;
4FZI;
4F40;
3WG6;
3WCZ;
3VXG;
3UZZ;
3UZY;
3UZX;
3UZW;
3QKZ;
3O3R;
3LN3;
3H7U;
3H7R;
3H4G;
3G1R;
3FX4;
3FJN;
3F7J;
3DOP;
3D3F;
3CV7;
3CV6;
3COT;
3CMF;
3CAV;
3CAS;
3CAQ;
3BV7;
3BUV;
3BUR;
3B3D;
2WZT;
2WZM;
2VDG;
2QXW;
2PDK;
2P5N;
2IPG;
2IPF;
2HEJ;
2HE8;
2HE5;
2FVL;
2FGB;
2BGS;
2BGQ;
2ALR;
1ZUA;
1VBJ;
1HQT;
1CWN;
1AE4;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.2 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.2 |
| KEGG Enzyme Link: | KEGG1.1.1.2 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.2 |
| ExPASy Enzyme Link: | ExPASy1.1.1.2 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.2 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.2 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.2 |
| RHEA:15937 | a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The enzymatic reduction of retinal to retinol in rat intestine. | Fidge NH, Goodman DS | 1968 Aug 25 | 4300551 |
| Triphosphopyridine nucleotide-linked aldehyde reductase. I. Purification and properties of the enzyme from pig kidney cortex. | Bosron WF, Prairie RL | 1972 Jul 25 | 4402936 |
| Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain. | Tabakoff B, Erwin VG | 1970 Jun | 4393513 |
| Metabolism of 2-oxoaldehyde in yeasts. Purification and characterization of NADPH-dependent methylglyoxal-reducing enzyme from Saccharomyces cerevisiae. | Murata K, Fukuda Y, Simosaka M, Watanabe K, Saikusa T, Kimura A | 1985 Sep 16 | 3896793 |
| Toward aldehyde and alkane production by removing aldehyde reductase activity in Escherichia coli. | Rodriguez GM, Atsumi S | 2014 Sep | 25108218 |
| Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae. | Chen CN, Porubleva L, Shearer G, Svrakic M, Holden LG, Dover JL, Johnston M, Chitnis PR, Kohl DH | 2003 Apr 30 | 12722185 |
| In vivo role of aldehyde reductase. | Takahashi M, Miyata S, Fujii J, Inai Y, Ueyama S, Araki M, Soga T, Fujinawa R, Nishitani C, Ariki S, Shimizu T, Abe T, Ihara Y, Nishikimi M, Kozutsumi Y, Taniguchi N, Kuroki Y | 2012 Nov | 22820017 |