EC number:1.1.1.201

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.201
Description:7-beta-hydroxysteroid dehydrogenase (NADP(+)).
Alternative Name: NADP-dependent 7-beta-hydroxysteroid dehydrogenase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.201
BRENDA Enzyme Link: BRENDA 1.1.1.201
KEGG Enzyme Link: KEGG1.1.1.201
BioCyc Enzyme Link: BioCyc 1.1.1.201
ExPASy Enzyme Link: ExPASy1.1.1.201
EC2PDB Enzyme Link: EC2PDB 1.1.1.201
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.201
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.201
IntEnz Enzyme Link: IntEnz 1.1.1.201
MEDLINE Enzyme Link: MEDLINE 1.1.1.201

EC number:1.1.1.201

MSA:

1.1.1.201;
Phylogenetic Tree:

1.1.1.201;
Uniprot:
M-CSA:
RHEA:20233 a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + H(+) + NADPH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
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References

TitleAuthorsDatePubMed ID
Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens.Hirano S, Masuda N1982 May6954878
Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum.MacDonald IA, Roach PD1981 Aug 246945134
Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms.MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV1982 Nov6758698
Contribution of the 7β-hydroxysteroid dehydrogenase from Ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colon.Lee JY, Arai H, Nakamura Y, Fukiya S, Wada M, Yokota A2013 Nov23729502