EC number:1.1.1.21
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.21 | ||
|---|---|---|---|
| Description: | Aldehyde reductase. | ||
| Alternative Name: |
Polyol dehydrogenase (NADP(+)). Aldose reductase. | ||
| Prosite: | PDOC00061; | ||
| PDB: |
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| Cath: | 3.20.20.10; 3.20.20.100; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.21 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.21 |
| KEGG Enzyme Link: | KEGG1.1.1.21 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.21 |
| ExPASy Enzyme Link: | ExPASy1.1.1.21 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.21 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.21 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.21 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.21 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.21 |
| RHEA:12785 | an alditol + NAD(+) = an aldose + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and partial characterization of an aldo-keto reductase from Saccharomyces cerevisiae. | Kuhn A, van Zyl C, van Tonder A, Prior BA | 1995 Apr | 7747971 |
| Purification and properties of calf liver aldose reductase. | Attwood MA, Doughty CC | 1974 Dec 29 | 4216364 |
| Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis. | Sundaram K, Dhagat U, Endo S, Chung R, Matsunaga T, Hara A, El-Kabbani O | 2011 Jan 15 | 21168333 |
| Rat aldose reductase-like protein (AKR1B14) efficiently reduces the lipid peroxidation product 4-oxo-2-nonenal. | Endo S, Matsunaga T, Fujita A, Tajima K, El-Kabbani O, Hara A | 2010 | 21048316 |
| [Aldose reductase]. | HERS HG | 1960 Jan 1 | 14401390 |
| Three genes whose expression is induced by stress in Saccharomyces cerevisiae. | Garay-Arroyo A, Covarrubias AA | 1999 Jul | 10407268 |
| RHEA:12789 | an alditol + NADP(+) = an aldose + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and partial characterization of an aldo-keto reductase from Saccharomyces cerevisiae. | Kuhn A, van Zyl C, van Tonder A, Prior BA | 1995 Apr | 7747971 |
| Purification and properties of calf liver aldose reductase. | Attwood MA, Doughty CC | 1974 Dec 29 | 4216364 |
| Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis. | Sundaram K, Dhagat U, Endo S, Chung R, Matsunaga T, Hara A, El-Kabbani O | 2011 Jan 15 | 21168333 |
| Rat aldose reductase-like protein (AKR1B14) efficiently reduces the lipid peroxidation product 4-oxo-2-nonenal. | Endo S, Matsunaga T, Fujita A, Tajima K, El-Kabbani O, Hara A | 2010 | 21048316 |
| [Aldose reductase]. | HERS HG | 1960 Jan 1 | 14401390 |
| Three genes whose expression is induced by stress in Saccharomyces cerevisiae. | Garay-Arroyo A, Covarrubias AA | 1999 Jul | 10407268 |
| RHEA:25225 | L-arabinitol + NAD(+) = H(+) + L-arabinose + NADH |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[*:3].[*:4]-[OH;+0:5]).[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:5]-[*:4].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Fungal arabinan and L-arabinose metabolism. | Seiboth B, Metz B | 2011 Mar | 21212945 |
| RHEA:25229 | L-arabinitol + NADP(+) = H(+) + L-arabinose + NADPH |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[*:3].[*:4]-[OH;+0:5]).[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:5]-[*:4].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Fungal arabinan and L-arabinose metabolism. | Seiboth B, Metz B | 2011 Mar | 21212945 |
| RHEA:37963 | galactitol + NAD(+) = D-galactose + H(+) + NADH |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[*:3].[*:4]-[OH;+0:5]).[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1.[*:4]-[O;H0;+0:5]-[CH;+0:2](-[*:1])-[*:3] |
| Reaction |  |
| Core-to-Core |
| RHEA:37967 | galactitol + NADP(+) = D-galactose + H(+) + NADPH |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[*:3].[*:4]-[OH;+0:5]).[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1.[*:4]-[O;H0;+0:5]-[CH;+0:2](-[*:1])-[*:3] |
| Reaction |  |
| Core-to-Core |