EC number:1.1.1.214
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.214 |
|---|---|
| Description: | 2-dehydropantolactone reductase (Si-specific). |
| Alternative Name: |
Ketopantoyl lactone reductase. 2-ketopantoyl lactone reductase. 2-dehydropantoyl-lactone reductase (B-specific). 2-dehydropantolactone reductase (B-specific). |
| Cath: | 3.20.20.10; 3.20.20.100; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.214 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.214 |
| KEGG Enzyme Link: | KEGG1.1.1.214 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.214 |
| ExPASy Enzyme Link: | ExPASy1.1.1.214 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.214 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.214 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.214 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.214 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.214 |
EC number:1.1.1.214
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:18981 | (R)-pantolactone + NADP(+) = 2-dehydropantolactone + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Ketopantoyl lactone and ketopantoic acid reductases. Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase. | King HL Jr, Dyar RE, Wilken DR | 1974 Aug 10 | 4603075 |
| Ketopantoyl-lactone reductase from Candida parapsilosis: purification and characterization as a conjugated polyketone reductase. | Hata H, Shimizu S, Hattori S, Yamada H | 1989 Feb 24 | 2644973 |
| Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate. | Wilken DR, King HL Jr, Dyar RE | 1975 Mar 25 | 234966 |
| Isolation and primary structural analysis of two conjugated polyketone reductases from Candida parapsilosis. | Hidalgo AR, Akond MA, Kita K, Kataoka M, Shimizu S | 2001 Dec | 11826979 |