EC number:1.1.1.218
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.218 | ||
|---|---|---|---|
| Description: | Morphine 6-dehydrogenase. | ||
| Alternative Name: |
Naloxone reductase. | ||
| Prosite: | PDOC00061; | ||
| PDB: |
|
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.218 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.218 |
| KEGG Enzyme Link: | KEGG1.1.1.218 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.218 |
| ExPASy Enzyme Link: | ExPASy1.1.1.218 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.218 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.218 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.218 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.218 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.218 |
EC number:1.1.1.218
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:14321 | morphine + NADP(+) = H(+) + morphinone + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase. | Yamano S, Nishida F, Toki S | 1986 Dec 1 | 3539118 |
| Purification and characterization of guinea pig liver morphine 6-dehydrogenase. | Yamano S, Kageura E, Ishida T, Toki S | 1985 May 10 | 2580834 |
| RHEA:14317 | morphine + NAD(+) = H(+) + morphinone + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase. | Yamano S, Nishida F, Toki S | 1986 Dec 1 | 3539118 |
| Purification and characterization of guinea pig liver morphine 6-dehydrogenase. | Yamano S, Kageura E, Ishida T, Toki S | 1985 May 10 | 2580834 |