EC number:1.1.1.219
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.219 |
|---|---|
| Description: | Dihydroflavanol 4-reductase. |
| Alternative Name: |
NADPH-dihydromyricetin reductase. Dihydrokaempferol 4-reductase. Dihydroflavonol 4-reductase. |
| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.219 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.219 |
| KEGG Enzyme Link: | KEGG1.1.1.219 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.219 |
| ExPASy Enzyme Link: | ExPASy1.1.1.219 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.219 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.219 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.219 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.219 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.219 |
EC number:1.1.1.219
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:54444 | a (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of (+)dihydroflavonol (3-hydroxyflavanone) 4-reductase from flowers of Dahlia variabilis. | Fischer D, Stich K, Britsch L, Grisebach H | 1988 Jul | 3293532 |
| Molecular characterization and expression analysis of dihydroflavonol 4-reductase (DFR) gene in Saussurea medusa. | Li H, Qiu J, Chen F, Lv X, Fu C, Zhao D, Hua X, Zhao Q | 2012 Mar | 21701830 |
| Flavan-3-ol Biosynthesis : The Conversion of (+)-Dihydromyricetin to Its Flavan-3,4-Diol (Leucodelphinidin) and to (+)-Gallocatechin by Reductases Extracted from Tissue Cultures of Ginkgo biloba and Pseudotsuga menziesii. | Stafford HA, Lester HH | 1985 Aug | 16664326 |
| Molecular cloning, substrate specificity of the functionally expressed dihydroflavonol 4-reductases from Malus domestica and Pyrus communis cultivars and the consequences for flavonoid metabolism. | Fischer TC, Halbwirth H, Meisel B, Stich K, Forkmann G | 2003 Apr 15 | 12667486 |
| RHEA:23016 | (2R,3S,4S)-3,4-leucopelargonidin + NADP(+) = (2R,3R)-dihydrokaempferol + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning, substrate specificity of the functionally expressed dihydroflavonol 4-reductases from Malus domestica and Pyrus communis cultivars and the consequences for flavonoid metabolism. | Fischer TC, Halbwirth H, Meisel B, Stich K, Forkmann G | 2003 Apr 15 | 12667486 |
| Molecular cloning and characterization of three genes encoding dihydroflavonol-4-reductase from Ginkgo biloba in anthocyanin biosynthetic pathway. | Hua C, Linling L, Shuiyuan C, Fuliang C, Feng X, Honghui Y, Conghua W | 2013 | 23991027 |