EC number:1.1.1.222
| ID: | 1.1.1.222 |
|---|---|
| Description: | (R)-4-hydroxyphenyllactate dehydrogenase. |
| Alternative Name: |
(R)-aromatic lactate dehydrogenase. |
3D structure
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| RHEA:10780 | (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli. | Sévin DC, Fuhrer T, Zamboni N, Sauer U | 2017 Feb | 27941785 |
| Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei. | Kim KH, Janiak V, Petersen M | 2004 Feb | 15284489 |
| HPPR encodes the hydroxyphenylpyruvate reductase required for the biosynthesis of hydrophilic phenolic acids in Salvia miltiorrhiza. | Wang GQ, Chen JF, Yi B, Tan HX, Zhang L, Chen WS | 2017 Dec | 29329649 |
| Molecular cloning and characterization of tyrosine aminotransferase and hydroxyphenylpyruvate reductase, and rosmarinic acid accumulation in Scutellaria baicalensis. | Kim YB, Uddina MR, Kim Y, Park CG, Park SU | 2014 Sep | 25918800 |
| RHEA:10776 | (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei. | Kim KH, Janiak V, Petersen M | 2004 Feb | 15284489 |
| HPPR encodes the hydroxyphenylpyruvate reductase required for the biosynthesis of hydrophilic phenolic acids in Salvia miltiorrhiza. | Wang GQ, Chen JF, Yi B, Tan HX, Zhang L, Chen WS | 2017 Dec | 29329649 |
| Molecular cloning and characterization of tyrosine aminotransferase and hydroxyphenylpyruvate reductase, and rosmarinic acid accumulation in Scutellaria baicalensis. | Kim YB, Uddina MR, Kim Y, Park CG, Park SU | 2014 Sep | 25918800 |