EC number:1.1.1.23
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.23 | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Description: | Histidinol dehydrogenase. | ||||||||||||||
| Prosite: | PDOC00534; | ||||||||||||||
| PDB: |
» hide |
||||||||||||||
| Cath: | 1.10.287.10; 1.10.287.1080; 1.20.5.130; 1.20.5.1300; 4.10.80.70; 3.40.50.1980; 3.10.20.400; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.23 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.23 |
| KEGG Enzyme Link: | KEGG1.1.1.23 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.23 |
| ExPASy Enzyme Link: | ExPASy1.1.1.23 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.23 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.23 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.23 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.23 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.23 |
| RHEA:20641 | H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[c;H0;+0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[n+;H0:9](-[*:10]):[cH;+0:11]:1.[*:12]-[n+;H0:13]1:[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:[c;H0;+0:17](-[*:18]):[cH;+0:19]:1.[OH2;+0:20]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[OH;+0:20].[*:4]-[C;H0;+0:5]1=[CH;+0:11]-[N;H0;+0:9](-[*:10])-[CH;+0:8]=[CH;+0:7]-[CH2;+0:6]-1.[*:12]-[N;H0;+0:13]1-[CH;+0:14]=[CH;+0:15]-[CH2;+0:16]-[C;H0;+0:17](-[*:18])=[CH;+0:19]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and functional conservation of histidinol dehydrogenase between plants and microbes. | Nagai A, Ward E, Beck J, Tada S, Chang JY, Scheidegger A, Ryals J | 1991 May 15 | 2034659 |
| Purification and characterization of histidinol dehydrogenase from cabbage. | Nagai A, Scheidegger A | 1991 Jan | 1989490 |
| Brucella suis histidinol dehydrogenase: synthesis and inhibition studies of a series of substituted benzylic ketones derived from histidine. | Abdo MR, Joseph P, Boigegrain RA, Liautard JP, Montero JL, Köhler S, Winum JY | 2007 Jul 1 | 17481905 |
| Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase. | Barbosa JA, Sivaraman J, Li Y, Larocque R, Matte A, Schrag JD, Cygler M | 2002 Feb 19 | 11842181 |