EC Tree |
1. Oxidoreductases |
1.1 Acting on the CH-OH group of donors |
1.1.1 With NAD+ or NADP+ as acceptor |
ID: | 1.1.1.231 |
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Description: | 15-hydroxyprostaglandin-I dehydrogenase (NADP(+)). |
Alternative Name: |
Prostacyclin dehydrogenase. PG I2 dehydrogenase. |
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.UniProtKB Enzyme Link: | UniProtKB 1.1.1.231 |
BRENDA Enzyme Link: | BRENDA 1.1.1.231 |
KEGG Enzyme Link: | KEGG1.1.1.231 |
BioCyc Enzyme Link: | BioCyc 1.1.1.231 |
ExPASy Enzyme Link: | ExPASy1.1.1.231 |
EC2PDB Enzyme Link: | EC2PDB 1.1.1.231 |
ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.231 |
PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.231 |
IntEnz Enzyme Link: | IntEnz 1.1.1.231 |
MEDLINE Enzyme Link: | MEDLINE 1.1.1.231 |
MSA: | |
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Phylogenetic Tree: | |
Uniprot: | |
M-CSA: |
RHEA:21420 | NADP(+) + prostaglandin I2 = 15-dehydro-prostaglandin I2 + H(+) + NADPH |
RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
Reaction | ![]() |
Core-to-Core |
Title | Authors | Date | PubMed ID |
---|---|---|---|
Isolation and properties of an NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney. | Korff JM, Jarabak J | 1982 | 6182444 |