EC number:1.1.1.232

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.232
Description:15-hydroxyicosatetraenoate dehydrogenase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.232
BRENDA Enzyme Link: BRENDA 1.1.1.232
KEGG Enzyme Link: KEGG1.1.1.232
BioCyc Enzyme Link: BioCyc 1.1.1.232
ExPASy Enzyme Link: ExPASy1.1.1.232
EC2PDB Enzyme Link: EC2PDB 1.1.1.232
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.232
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.232
IntEnz Enzyme Link: IntEnz 1.1.1.232
MEDLINE Enzyme Link: MEDLINE 1.1.1.232

EC number:1.1.1.232

MSA:

1.1.1.232;
Phylogenetic Tree:

1.1.1.232;
Uniprot:
M-CSA:
RHEA:23264 (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
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References

TitleAuthorsDatePubMed ID
15-Hydroxyeicosatetraenoic acid dehydrogenase activity in microsomal fraction of mouse liver homogenate.Sok DE, Kang JB, Shin HD1988 Oct 143052453
RHEA:23260 (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid.Liu X, Zhang S, Arora JS, Snyder NW, Shah SJ, Blair IA2011 Dec 1921916491