EC number:1.1.1.267

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.267
Description:1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Alternative Name: DXP-reductoisomerase.
1-deoxyxylulose-5-phosphate reductoisomerase.
Cath: 1.10.1740.10; 3.40.50.720;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.267
BRENDA Enzyme Link: BRENDA 1.1.1.267
KEGG Enzyme Link: KEGG1.1.1.267
BioCyc Enzyme Link: BioCyc 1.1.1.267
ExPASy Enzyme Link: ExPASy1.1.1.267
EC2PDB Enzyme Link: EC2PDB 1.1.1.267
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.267
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.267
IntEnz Enzyme Link: IntEnz 1.1.1.267
MEDLINE Enzyme Link: MEDLINE 1.1.1.267

EC number:1.1.1.267

MSA:

1.1.1.267;
Phylogenetic Tree:

1.1.1.267;
Uniprot:
M-CSA:
RHEA:13717 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])(-[CH3;+0:4])-[CH2;+0:5]-[OH;+0:6].[*:7]-[n+;H0:8]1:[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:1>>[*:1]-[CH;+0:2](-[*:3])-[C;H0;+0:5](-[CH3;+0:4])=[O;H0;+0:6].[*:7]-[N;H0;+0:8]1-[CH;+0:9]=[CH;+0:10]-[CH2;+0:11]-[C;H0;+0:12](-[*:13])=[CH;+0:14]-1
Reaction
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References

TitleAuthorsDatePubMed ID
A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis.Takahashi S, Kuzuyama T, Watanabe H, Seto H1998 Aug 189707569
A secondary kinetic isotope effect study of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase-catalyzed reaction: evidence for a retroaldol-aldol rearrangement.Munos JW, Pu X, Mansoorabadi SO, Kim HJ, Liu HW2009 Feb 1819159292
1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin.Dhiman RK, Schaeffer ML, Bailey AM, Testa CA, Scherman H, Crick DC2005 Dec16321944