EC number:1.1.1.27

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.27
Description:L-lactate dehydrogenase.
Alternative Name: L-lactic dehydrogenase.
L-lactic acid dehydrogenase.
Prosite: PDOC00062;
PDB:
PDBScop
1HYH 8057347; 8057348; 8057347; 8057348; 8057347; 8057348; 8057347; 8057348;
1LTH 8057325; 8057326; 8057325; 8057326;
1LLD 8057325; 8057326; 8057325; 8057326;
2ZQZ 8057323; 8057324; 8057323; 8057324; 8057323; 8057324; 8057323; 8057324; 8057323; 8057324; 8057323; 8057324;
2ZQY 8057323; 8057324; 8057323; 8057324; 8057323; 8057324; 8057323; 8057324;
 » show all
Cath: 3.40.50.720; 3.90.110.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.27
BRENDA Enzyme Link: BRENDA 1.1.1.27
KEGG Enzyme Link: KEGG1.1.1.27
BioCyc Enzyme Link: BioCyc 1.1.1.27
ExPASy Enzyme Link: ExPASy1.1.1.27
EC2PDB Enzyme Link: EC2PDB 1.1.1.27
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.27
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.27
IntEnz Enzyme Link: IntEnz 1.1.1.27
MEDLINE Enzyme Link: MEDLINE 1.1.1.27

EC number:1.1.1.27

MSA:

1.1.1.27;
Phylogenetic Tree:

1.1.1.27;
Uniprot:
M-CSA:
RHEA:23444 (S)-lactate + NAD(+) = H(+) + NADH + pyruvate
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
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References

TitleAuthorsDatePubMed ID
Cloning, nucleotide sequence, and transcriptional analysis of the Pediococcus acidilactici L-(+)-lactate dehydrogenase gene.Garmyn D, Ferain T, Bernard N, Hols P, Delcour J1995 Jan7887607
Crystal structure of Plasmodium berghei lactate dehydrogenase indicates the unique structural differences of these enzymes are shared across the Plasmodium genus.Winter VJ, Cameron A, Tranter R, Sessions RB, Brady RL2003 Sep12967707
IS981-mediated adaptive evolution recovers lactate production by ldhB transcription activation in a lactate dehydrogenase-deficient strain of Lactococcus lactis.Bongers RS, Hoefnagel MH, Starrenburg MJ, Siemerink MA, Arends JG, Hugenholtz J, Kleerebezem M2003 Aug12867459
Cloning of the L-lactate dehydrogenase gene from the ruminal bacterium Selenomonas ruminantium HD4.Evans JD, Martin SA2002 Mar11821921