EC number:1.1.1.283
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.283 |
|---|---|
| Description: | Methylglyoxal reductase (NADPH). |
| Alternative Name: |
Methylglyoxal reductase (NADPH-dependent). Lactaldehyde dehydrogenase (NADP(+)). |
| Cath: | 3.20.20.10; 3.20.20.100; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.283 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.283 |
| KEGG Enzyme Link: | KEGG1.1.1.283 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.283 |
| ExPASy Enzyme Link: | ExPASy1.1.1.283 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.283 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.283 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.283 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.283 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.283 |
EC number:1.1.1.283
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:21748 | (S)-lactaldehyde + NADP(+) = H(+) + methylglyoxal + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Metabolism of 2-oxoaldehyde in yeasts. Purification and characterization of NADPH-dependent methylglyoxal-reducing enzyme from Saccharomyces cerevisiae. | Murata K, Fukuda Y, Simosaka M, Watanabe K, Saikusa T, Kimura A | 1985 Sep 16 | 3896793 |
| Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae. | Chen CN, Porubleva L, Shearer G, Svrakic M, Holden LG, Dover JL, Johnston M, Chitnis PR, Kohl DH | 2003 Apr 30 | 12722185 |
| Crystallization and preliminary crystallographic analysis of Gre2p, an NADP(+)-dependent alcohol dehydrogenase from Saccharomyces cerevisiae. | Breicha K, Müller M, Hummel W, Niefind K | 2010 Jul 1 | 20606287 |
| Highly efficient and stereoselective biosynthesis of (2S,5S)-hexanediol with a dehydrogenase from Saccharomyces cerevisiae. | Müller M, Katzberg M, Bertau M, Hummel W | 2010 Apr 7 | 20237665 |
| Asymmetric synthesis of (S)-3-chloro-1-phenyl-1-propanol using Saccharomyces cerevisiae reductase with high enantioselectivity. | Choi YH, Choi HJ, Kim D, Uhm KN, Kim HK | 2010 Jun | 20111861 |
| A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase. | Hauser M, Horn P, Tournu H, Hauser NC, Hoheisel JD, Brown AJ, Dickinson JR | 2007 Jan | 16999827 |