EC number:1.1.1.30

Enzyme

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EC Tree
     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.30
Description:3-hydroxybutyrate dehydrogenase.
Alternative Name: D-beta-hydroxybutyrate dehydrogenase.
Prosite: PDOC00060;
PDB:
PDBScop
1WNT 8058520; 8058521; 8058520; 8058521; 8058520; 8058521; 8058520; 8058521;
3D3W 8058520; 8058521; 8058520; 8058521;
1PR9 8058520; 8058521; 8058520; 8058521;
3RJ9 8058516; 8058517; 8058516; 8058517; 8058516; 8058517; 8058516; 8058517; 8058516; 8058517; 8058516; 8058517;
3RJ5 8058516; 8058517; 8058516; 8058517;
 » show all
Cath: 3.40.50.720;

3D structure

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PDB

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1WNT; 3D3W; 1PR9; 3RJ9; 3RJ5; 1SBY; 1B16; 1B15; 1B14; 1A4U; 1B2L; 1U7T; 2O23; 1SO8; 1N5D; 3GMD; 4NMH; 5QIJ; 5PGZ; 1Y5R; 1Y5M; 3LZ6; 3G49; 3DWF; 1XSE; 4DC1; 4DC0; 4DBZ; 3RI3; 3QRW; 3CSD; 2RHR; 2RHC; 2RH4; 1XR3; 1X7H; 1X7G; 1W4Z; 1AE1; 1NFR; 1NFQ; 1NFF; 1HXH; 2BGK; 2BGM; 2BGL; 1YDE; 5ICS; 6GBT; 6G4L; 6FFB; 6EMM; 5O7C; 5O72; 5O6Z; 5O6X; 5O6O; 5O43; 5O42; 5L7Y; 5L7W; 5L7T; 5JSF; 5JS6; 5ICM; 5HS6; 5EN4; 2AG5; 2GDZ; 1G0O; 1YBV; 1G0N; 1DOH; 2AE2; 1IPF; 1IPE; 2AE1; 1K2W; 1I01; 1Q7B; 1GEG; 3WYE; 1RWB; 1GEE; 1GCO; 1G6K; 1BDB; 2HSD; 1HDC; 1DIR; 1DHR; 1CYD; 4Z3D; 3BHM; 3BHJ; 3BHI; 2PFG; 1WMA; 1E6W; 1E3W; 1E3S; 2IRW; 5QII; 5PGY; 5PGX; 5PGW; 5PGV; 5PGU; 4K1L; 4IJW; 4IJV; 4IJU; 4HX5; 4C7K; 4C7J; 4BB5; 3TFQ; 3QQP; 3OQ1; 3HFG; 3H6K; 3EY4; 3D5Q; 3D4N; 3D3E; 3CH6; 3BZU; 3BYZ; 2RBE; 2BEL; 1XU9; 1XU7; 4YYZ; 4P38; 4HFR; 4BB6; 3PDJ; 3FRJ; 3FCO; 3CZR; 2ILT; 1XG5; 1P33; 3H4V; 1W0C; 5L4N; 5L42; 2QHX; 2BFP; 2BFO; 2BFM; 2BFA; 2BF7; 1E92; 1E7W; 1HDR; 2CDH; 1EDO; 2NTN; 1UZN; 1UZM; 1UZL; 1FMC; 1AHI; 1AHH; 1FDV; 1FDU; 6MNE; 6MNC; 6DTP; 6CGE; 6CGC; 3KM0; 1EQU; 3KLP; 3KLM; 3HB5; 3HB4; 3DHE; 3DEY; 1QYX; 1QYW; 1QYV; 1JTV; 1IOL; 1I5R; 1FDW; 1FDT; 1FDS; 1DHT; 1BHS; 1A27; 1ZBQ; 1MG5; 6IXJ; 5Z2L; 5OVL; 5OVK; 5OVJ; 5MSU; 5MSO; 5ITW; 5ITV; 5END; 4WJZ; 4RZI; 4RZH; 4N5N; 4N5M; 4N5L; 4K26; 4IS3; 4I08; 4HBG; 4FDA; 4FD3; 4CR8; 4CR7; 4CR6; 4CQM; 4CQL; 4BO9; 4BO8; 4BO7; 4BO6; 4BO5; 4BO4; 4BO3; 4BO2; 4BO1; 4BO0; 4BNZ; 4BNY; 4BNX; 4BNW; 4BNV; 4BNU; 4BNT; 4AG3; 4AFN; 3ZV6; 3ZV5; 3ZV4; 3ZV3; 3VZS; 3VZR; 3VZQ; 3VZP; 3V2H; 3U09; 3RWB; 3RSH; 3RRO; 3RKU; 3PGX; 3OSU; 3ORF; 3OML; 3O4R; 3NUG; 3NDR; 3KZV; 3KVO; 3F9I; 3F1L; 3AY7; 3AY6; 3AUU; 3AUT; 3AUS; 3A28; 2ZAT; 2Y99; 2Y93; 2PNF; 2PD6; 2P68; 2HRB; 2FWM; 2ET6; 2CFC;

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.30
BRENDA Enzyme Link: BRENDA 1.1.1.30
KEGG Enzyme Link: KEGG1.1.1.30
BioCyc Enzyme Link: BioCyc 1.1.1.30
ExPASy Enzyme Link: ExPASy1.1.1.30
EC2PDB Enzyme Link: EC2PDB 1.1.1.30
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.30
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.30
IntEnz Enzyme Link: IntEnz 1.1.1.30
MEDLINE Enzyme Link: MEDLINE 1.1.1.30

EC number:1.1.1.30

MSA:

1.1.1.30;
Phylogenetic Tree:

1.1.1.30;
Uniprot:
M-CSA:
RHEA:20521 (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Immunoaffinity purification and characterization of mitochondrial membrane-bound D-3-hydroxybutyrate dehydrogenase from Jaculus orientalis.Mountassif D, Andreoletti P, El Kebbaj Z, Moutaouakkil A, Cherkaoui-Malki M, Latruffe N, El Kebbaj MS2008 Sep 3018826626
Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase.Guo K, Lukacik P, Papagrigoriou E, Meier M, Lee WH, Adamski J, Oppermann U2006 Apr 1416380372
Molecular cloning and characterization of (R)-3-hydroxybutyrate dehydrogenase from human heart.Marks AR, McIntyre JO, Duncan TM, Erdjument-Bromage H, Tempst P, Fleischer S1992 Aug 51639787