EC number:1.1.1.31

Enzyme

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EC Tree
     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.31
Description:3-hydroxyisobutyrate dehydrogenase.
Prosite: PDOC00697;
PDB:
PDBScop
5Y8P
5Y8O
5Y8N
5Y8M
5Y8L
 » show all
Cath: 1.10.1040.10; 3.40.50.720;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.31
BRENDA Enzyme Link: BRENDA 1.1.1.31
KEGG Enzyme Link: KEGG1.1.1.31
BioCyc Enzyme Link: BioCyc 1.1.1.31
ExPASy Enzyme Link: ExPASy1.1.1.31
EC2PDB Enzyme Link: EC2PDB 1.1.1.31
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.31
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.31
IntEnz Enzyme Link: IntEnz 1.1.1.31
MEDLINE Enzyme Link: MEDLINE 1.1.1.31

EC number:1.1.1.31

MSA:

1.1.1.31;
Phylogenetic Tree:

1.1.1.31;
Uniprot:
M-CSA:
RHEA:31275 (S)-3-hydroxy-2-methylpropanoate + NAD(+) = (S)-methylmalonate semialdehyde + H(+) + NADH
RULE(radius=1) [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Purification and characterization of 3-hydroxyisobutyrate dehydrogenase from rabbit liver.Rougraff PM, Paxton R, Kuntz MJ, Crabb DW, Harris RA1988 Jan 53335502
Structure, interactions and action of <i>Mycobacterium tuberculosis</i> 3-hydroxyisobutyric acid dehydrogenase.Srikalaivani R, Singh A, Vijayan M, Surolia A2018 Aug 1429959185
Structural and biochemical characterization of the Bacillus cereus 3-hydroxyisobutyrate dehydrogenase.Park SC, Kim PH, Lee GS, Kang SG, Ko HJ, Yoon SI2016 Jun 327120461
RHEA:17681 3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + H(+) + NADH
RULE(radius=1) [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
3-Hydroxyisobutyrate Dehydrogenase Is Involved in Both, Valine and Isoleucine Degradation in <i>Arabidopsis thaliana</i>.Schertl P, Danne L, Braun HP2017 Sep28705827