EC number:1.1.1.314
| ID: | 1.1.1.314 |
|---|---|
| Description: | Germacrene A alcohol dehydrogenase. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
| RHEA:30667 | germacra-1(10),4,11(13)-trien-12-ol + H2O + 2 NADP(+) = germacra-1(10),4,11(13)-trien-12-oate + 3 H(+) + 2 NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[c;H0;+0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[n+;H0:9](-[*:10]):[cH;+0:11]:1.[*:12]-[n+;H0:13]1:[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:[c;H0;+0:17](-[*:18]):[cH;+0:19]:1.[OH2;+0:20]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[OH;+0:20].[*:4]-[C;H0;+0:5]1=[CH;+0:11]-[N;H0;+0:9](-[*:10])-[CH;+0:8]=[CH;+0:7]-[CH2;+0:6]-1.[*:12]-[N;H0;+0:13]1-[CH;+0:14]=[CH;+0:15]-[CH2;+0:16]-[C;H0;+0:17](-[*:18])=[CH;+0:19]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical conservation and evolution of germacrene A oxidase in asteraceae. | Nguyen DT, Göpfert JC, Ikezawa N, Macnevin G, Kathiresan M, Conrad J, Spring O, Ro DK | 2010 May 28 | 20351109 |
| Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450 (+)-germacrene a hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis. | de Kraker JW, Franssen MC, Dalm MC, de Groot A, Bouwmeester HJ | 2001 Apr | 11299372 |