EC number:1.1.1.34
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.34 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.34 |
| KEGG Enzyme Link: | KEGG1.1.1.34 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.34 |
| ExPASy Enzyme Link: | ExPASy1.1.1.34 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.34 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.34 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.34 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.34 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.34 |
| RHEA:15989 | (R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[SH;+0:5].[*:6]-[c;H0;+0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[n+;H0:11](-[*:12]):[cH;+0:13]:1.[*:14]-[n+;H0:15]1:[cH;+0:16]:[cH;+0:17]:[cH;+0:18]:[c;H0;+0:19](-[*:20]):[cH;+0:21]:1>>[*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[S;H0;+0:5]-[*:4].[*:6]-[C;H0;+0:7]1=[CH;+0:13]-[N;H0;+0:11](-[*:12])-[CH;+0:10]=[CH;+0:9]-[CH2;+0:8]-1.[*:14]-[N;H0;+0:15]1-[CH;+0:16]=[CH;+0:17]-[CH2;+0:18]-[C;H0;+0:19](-[*:20])=[CH;+0:21]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Haloferax volcanii: purification, characterization, and expression in Escherichia coli. | Bischoff KM, Rodwell VW | 1996 Jan | 8550415 |
| Isoprenoid synthesis in Halobacterium halobium. Modulation of 3-hydroxy-3-methylglutaryl coenzyme a concentration in response to mevalonate availability. | Cabrera JA, Bolds J, Shields PE, Havel CM, Watson JA | 1986 Mar 15 | 3633268 |
| Molecular mechanism for inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by rosuvastatin. | Holdgate GA, Ward WH, McTaggart F | 2003 Jun | 12773150 |
| Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase. | Tabernero L, Rodwell VW, Stauffacher CV | 2003 May 30 | 12621048 |
| Enterococcus faecalis acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesis. | Hedl M, Sutherlin A, Wilding EI, Mazzulla M, McDevitt D, Lane P, Burgner JW 2nd, Lehnbeuter KR, Stauffacher CV, Gwynn MN, Rodwell VW | 2002 Apr | 11914342 |