Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.35
Description:3-hydroxyacyl-CoA dehydrogenase.
Alternative Name: Beta-keto-reductase.
Beta-hydroxyacyl dehydrogenase.
Prosite: PDOC00065; PDOC00060;
PDB:
PDBScop
3HDH 8085160; 8085161; 8085160; 8085161; 8085160; 8085161;
2D3T 8029327; 8029329; 8041706; 8041708; 8029327; 8029329; 8041706; 8041708; 8001140; 8001143; 8001546; 8017508; 8001140; 8001143; 8001546; 8017508;
1WDM 8029327; 8029329; 8041706; 8041708; 8029327; 8029329; 8041706; 8041708; 8001140; 8001143; 8001546; 8017508; 8001140; 8001143; 8001546; 8017508;
1WDL 8029327; 8029329; 8041706; 8041708; 8001140; 8001143; 8001546; 8017508; 8001140; 8001143; 8001546; 8017508; 8029327; 8029329; 8041706; 8041708;
1WDK 8001140; 8001143; 8001546; 8017508; 8029327; 8029329; 8041706; 8041708; 8001140; 8001143; 8001546; 8017508; 8029327; 8029329; 8041706; 8041708;
 » show all

Cath: 1.10.1040.10; 1.10.1040.50; 1.20.5.2720; 1.20.5.30; 1.20.5.3020; 3.40.50.720; 3.90.226.10;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.35
BRENDA Enzyme Link: BRENDA 1.1.1.35
KEGG Enzyme Link: KEGG1.1.1.35
BioCyc Enzyme Link: BioCyc 1.1.1.35
ExPASy Enzyme Link: ExPASy1.1.1.35
EC2PDB Enzyme Link: EC2PDB 1.1.1.35
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.35
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.35
IntEnz Enzyme Link: IntEnz 1.1.1.35
MEDLINE Enzyme Link: MEDLINE 1.1.1.35
MSA:

1.1.1.35;

Phylogenetic Tree:

1.1.1.35;

Uniprot:
M-CSA:
RHEA:22432 a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1
Reaction
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References

TitleAuthorsDatePubMed ID
Identification of a rice RNA- and microtubule-binding protein as the multifunctional protein, a peroxisomal enzyme involved in the beta -oxidation of fatty acids.Chuong SD, Mullen RT, Muench DG2002 Jan 2511706039
Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD.Shafqat N, Marschall HU, Filling C, Nordling E, Wu XQ, Björk L, Thyberg J, Mårtensson E, Salim S, Jörnvall H, Oppermann U2003 Nov 1512917011
Crystalline beta-hydroxybutyryl dehydrogenase from pig heart.STERN JR1957 Nov13499396
Studies on the fatty acid oxidizing system of animal tissues. VI. beta-Hydroxyacyl coenzyme A dehydrogenase.WAKIL SJ, GREEN DE, MII S, MAHLER HR1954 Apr13163047
The enzymic oxidation of alpha- and 2-beta-hydroxybutyrate.LEHNINGER AL, GREVILLE GD1953 Sep-Oct13115428