EC number:1.1.1.36
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.36 | ||
|---|---|---|---|
| Description: | Acetoacetyl-CoA reductase. | ||
| Prosite: | PDOC00060; | ||
| PDB: |
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| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.36 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.36 |
| KEGG Enzyme Link: | KEGG1.1.1.36 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.36 |
| ExPASy Enzyme Link: | ExPASy1.1.1.36 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.36 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.36 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.36 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.36 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.36 |
| RHEA:45796 | (3R)-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of (R)-3-hydroxybutyryl-CoA dehydrogenase PhaB from Ralstonia eutropha. | Kim J, Chang JH, Kim EJ, Kim KJ | 2014 Jan 17 | 24211201 |
| Directed evolution and structural analysis of NADPH-dependent Acetoacetyl Coenzyme A (Acetoacetyl-CoA) reductase from Ralstonia eutropha reveals two mutations responsible for enhanced kinetics. | Matsumoto K, Tanaka Y, Watanabe T, Motohashi R, Ikeda K, Tobitani K, Yao M, Tanaka I, Taguchi S | 2013 Oct | 23913421 |
| RHEA:22256 | a (3R)-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of (R)-3-hydroxybutyryl-CoA dehydrogenase PhaB from Ralstonia eutropha. | Kim J, Chang JH, Kim EJ, Kim KJ | 2014 Jan 17 | 24211201 |
| Directed evolution and structural analysis of NADPH-dependent Acetoacetyl Coenzyme A (Acetoacetyl-CoA) reductase from Ralstonia eutropha reveals two mutations responsible for enhanced kinetics. | Matsumoto K, Tanaka Y, Watanabe T, Motohashi R, Ikeda K, Tobitani K, Yao M, Tanaka I, Taguchi S | 2013 Oct | 23913421 |
| Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution. | Haapalainen AM, Koski MK, Qin YM, Hiltunen JK, Glumoff T | 2003 Jan | 12517343 |