EC number:1.1.1.37

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.37
Description:Malate dehydrogenase.
Alternative Name: Malic dehydrogenase.
Prosite: PDOC00066;
PDB:
PDBScop
1CIV 8057337; 8057338;
7MDH 8057335; 8057336; 8057335; 8057336; 8057335; 8057336; 8057335; 8057336;
1MLD 8057333; 8057334; 8057333; 8057334; 8057333; 8057334; 8057333; 8057334;
4KDF 8057331; 8057332; 8057331; 8057332; 8057331; 8057332; 8057331; 8057332;
4KDE 8057331; 8057332; 8057331; 8057332;
 » show all
Cath: 1.10.1530.10; 1.20.5.460; 3.30.1370.60; 3.40.50.720; 3.90.110.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.37
BRENDA Enzyme Link: BRENDA 1.1.1.37
KEGG Enzyme Link: KEGG1.1.1.37
BioCyc Enzyme Link: BioCyc 1.1.1.37
ExPASy Enzyme Link: ExPASy1.1.1.37
EC2PDB Enzyme Link: EC2PDB 1.1.1.37
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.37
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.37
IntEnz Enzyme Link: IntEnz 1.1.1.37
MEDLINE Enzyme Link: MEDLINE 1.1.1.37

EC number:1.1.1.37

MSA:

1.1.1.37;
Phylogenetic Tree:

1.1.1.37;
Uniprot:
M-CSA:
RHEA:21432 (S)-malate + NAD(+) = H(+) + NADH + oxaloacetate
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
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References

TitleAuthorsDatePubMed ID
Two malate dehydrogenases in Methanobacterium thermoautotrophicum.Thompson H, Tersteegen A, Thauer RK, Hedderich R1998 Jul9639601
Beef heart malic dehydrogenases. VII. Reactivity of sulfhydryl groups and conformation of the supernatant enzyme.Guha A, Englard S, Listowsky I1968 Feb 105637713
Purification and properties of Drosophila malate dehydrogenases.McReynolds MS, Kitto GB1970 Feb 114313528
Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.Fan J, Teng X, Liu L, Mattaini KR, Looper RE, Vander Heiden MG, Rabinowitz JD2015 Feb 2025406093
Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix.Kawakami R, Sakuraba H, Goda S, Tsuge H, Ohshima T2009 Oct19555779
Some molecular and kinetic properties of heart malic dehydrogenase.WOLFE RG, NEILANDS JB1956 Jul13345798