EC number:1.1.1.40

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.40
Description:Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)).
Alternative Name: Pyruvic-malic carboxylase.
NADP-malic enzyme.
Malic enzyme.
Prosite: PDOC00294;
PDB:
PDBScop
Cath: 1.20.1370.30; 3.30.2330.30; 3.40.50.720; 3.40.50.10380;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.40
BRENDA Enzyme Link: BRENDA 1.1.1.40
KEGG Enzyme Link: KEGG1.1.1.40
BioCyc Enzyme Link: BioCyc 1.1.1.40
ExPASy Enzyme Link: ExPASy1.1.1.40
EC2PDB Enzyme Link: EC2PDB 1.1.1.40
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.40
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.40
IntEnz Enzyme Link: IntEnz 1.1.1.40
MEDLINE Enzyme Link: MEDLINE 1.1.1.40

EC number:1.1.1.40

MSA:

1.1.1.40;
Phylogenetic Tree:

1.1.1.40;
Uniprot:
M-CSA:
RHEA:18253 (S)-malate + NADP(+) = CO2 + NADPH + pyruvate
RULE(radius=1) [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[C;H0;+0:10](-[OH;+0:11])-[CH2;+0:12]-[CH;+0:13](-[*:14])-[OH;+0:15]>>[*:14]-[C;H0;+0:13](-[CH3;+0:12])=[O;H0;+0:15].[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10]=[O;H0;+0:11]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Biosynthesis of dicarboxylic acids by carbon dioxide fixation; isolation and properties of an enzyme from pigeon liver catalyzing the reversible oxidative decarboxylation of 1-malic acid.OCHOA S, MEHLER AH, KORNBERG A1948 Jul18871257
Physiological studies on acid metabolism. 7. Malic enzyme from Kalanchoe crenata: effects of carbon dioxide concentration.WALKER DA1960 Feb13842495
Some properties of the malic enzyme of pigeon liver. 2. Synthesis of malate from pyruvate.STICKLAND RG1959 Dec13834657
Some properties of the malic enzyme of pigeon liver. 1. Conversion of malate into pyruvate.STICKLAND RG1959 Dec13834656
Purification and properties of pigeon liver malic enzyme.RUTTER WJ, LARDY HA1958 Aug13563505
Biosynthesis of dicarboxylic acids by carbon dioxide fixation. VII. Equilibrium of malic enzyme reaction.HARARY I, KOREY SR, OCHOA S1953 Aug13084629
RHEA:15641 H(+) + oxaloacetate = CO2 + pyruvate
RULE(radius=1) [C:1][C:2](=[O:3])[OH:4]>>[C:1].[O:3]=[C:2]=[O:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Studies on regulatory functions of malic enzymes. IV. Effects of sulfhydryl group modification on the catalytic function of NAD-linked malic enzyme from Escherichia coli.Yamaguchi M1979 Aug225306
Biosynthesis of dicarboxylic acids by carbon dioxide fixation; isolation and properties of an enzyme from pigeon liver catalyzing the reversible oxidative decarboxylation of 1-malic acid.OCHOA S, MEHLER AH, KORNBERG A1948 Jul18871257
Biosynthesis of dicarboxylic acids by carbon dioxide fixation. V. Further study of the "malic" enzyme of Lactobacillus arabinosus.KAUFMAN S, KORKES S, DEL CAMPILLO A1951 Sep14917678
Physiological studies on acid metabolism. 7. Malic enzyme from Kalanchoe crenata: effects of carbon dioxide concentration.WALKER DA1960 Feb13842495
Some properties of the malic enzyme of pigeon liver. 2. Synthesis of malate from pyruvate.STICKLAND RG1959 Dec13834657
Some properties of the malic enzyme of pigeon liver. 1. Conversion of malate into pyruvate.STICKLAND RG1959 Dec13834656
Purification and properties of pigeon liver malic enzyme.RUTTER WJ, LARDY HA1958 Aug13563505
Biosynthesis of dicarboxylic acids by carbon dioxide fixation. VII. Equilibrium of malic enzyme reaction.HARARY I, KOREY SR, OCHOA S1953 Aug13084629