EC number:1.1.1.41

Enzyme

Download
EC Tree
     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.41
Description:Isocitrate dehydrogenase (NAD(+)).
Alternative Name: Nicotinamide adenine dinucleotide isocitrate dehydrogenase.
NAD-specific isocitrate dehydrogenase.
NAD-linked isocitrate dehydrogenase.
NAD isocitric dehydrogenase.
NAD isocitrate dehydrogenase.
NAD dependent isocitrate dehydrogenase.
Isocitric dehydrogenase.
Isocitric acid dehydrogenase.
Isocitrate dehydrogenase (NAD).
IDH.
Beta-ketoglutaric-isocitric carboxylase.
Prosite: PDOC00389;
PDB:
PDBScop
1WPW 8031301; 8043679; 8031301; 8043679;
2G4O 8030823; 8043202; 8030823; 8043202; 8030823; 8043202; 8030823; 8043202;
1W0D 8030823; 8043202; 8030823; 8043202; 8030823; 8043202; 8030823; 8043202;
1LWD 8030748; 8043127; 8030748; 8043127;
1VLC 8029068; 8041447;
 » show all
Cath: 3.30.1490.20; 3.30.470.20; 3.30.70.1570; 3.40.718.10; 3.40.50.20;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.41
BRENDA Enzyme Link: BRENDA 1.1.1.41
KEGG Enzyme Link: KEGG1.1.1.41
BioCyc Enzyme Link: BioCyc 1.1.1.41
ExPASy Enzyme Link: ExPASy1.1.1.41
EC2PDB Enzyme Link: EC2PDB 1.1.1.41
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.41
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.41
IntEnz Enzyme Link: IntEnz 1.1.1.41
MEDLINE Enzyme Link: MEDLINE 1.1.1.41

EC number:1.1.1.41

MSA:

1.1.1.41;
Phylogenetic Tree:

1.1.1.41;
Uniprot:
M-CSA:
RHEA:23632 D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[C;H0;+0:3](=[*:4])-[OH;+0:5])-[CH;+0:6](-[*:7])-[OH;+0:8].[*:9]-[n+;H0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[c;H0;+0:14](-[*:15]):[cH;+0:16]:1>>[*:1]-[CH2;+0:2]-[C;H0;+0:6](-[*:7])=[O;H0;+0:8].[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[CH;+0:12]-[CH2;+0:13]-[C;H0;+0:14](-[*:15])=[CH;+0:16]-1.[*:4]=[C;H0;+0:3]=[O;H0;+0:5]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.Miyazaki K2005 May 2715845397
Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase.Soundar S, Park JH, Huh TL, Colman RF2003 Dec 2614555658