EC number:1.1.1.42
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.42 | ||
|---|---|---|---|
| Description: | Isocitrate dehydrogenase (NADP(+)). | ||
| Alternative Name: |
oxalosuccinate carboxylase. Triphosphopyridine nucleotide-linked isocitrate dehydrogenase- Oxalsuccinic decarboxylase. Oxalosuccinate decarboxylase. NADP-specific isocitrate dehydrogenase. NADP-linked isocitrate dehydrogenase. NADP-dependent isocitric dehydrogenase. NADP-dependent isocitrate dehydrogenase. NADP(+)-linked isocitrate dehydrogenase. NADP(+)-IDH. NADP(+)-ICDH. NADP isocitric dehydrogenase. Isocitrate dehydrogenase (NADP-dependent). Isocitrate dehydrogenase (NADP). Isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase. Isocitrate (NADP) dehydrogenase. IDP. IDH. Dual-cofactor-specific isocitrate dehydrogenase. | ||
| Prosite: | PDOC00389; | ||
| PDB: |
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| Cath: | 3.30.70.1570; 3.40.718.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.42 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.42 |
| KEGG Enzyme Link: | KEGG1.1.1.42 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.42 |
| ExPASy Enzyme Link: | ExPASy1.1.1.42 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.42 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.42 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.42 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.42 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.42 |
| RHEA:19629 | isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[C;H0;+0:3](=[*:4])-[OH;+0:5])-[CH;+0:6](-[*:7])-[OH;+0:8].[*:9]-[n+;H0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[c;H0;+0:14](-[*:15]):[cH;+0:16]:1>>[*:1]-[CH2;+0:2]-[C;H0;+0:6](-[*:7])=[O;H0;+0:8].[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[CH;+0:12]-[CH2;+0:13]-[C;H0;+0:14](-[*:15])=[CH;+0:16]-1.[*:4]=[C;H0;+0:3]=[O;H0;+0:5] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical and phylogenetic characterization of isocitrate dehydrogenase from a hyperthermophilic archaeon, Archaeoglobus fulgidus. | Steen IH, Lien T, Birkeland NK | 1997 Nov | 9325430 |
| Isocitrate dehydrogenases from Haloferax volcanii and Sulfolobus solfataricus: enzyme purification, characterisation and N-terminal sequence. | Camacho ML, Brown RA, Bonete MJ, Danson MJ, Hough DW | 1995 Dec 1 | 8593959 |
| Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism. | Koh HJ, Lee SM, Son BG, Lee SH, Ryoo ZY, Chang KT, Park JW, Park DC, Song BJ, Veech RL, Song H, Huh TL | 2004 Sep 17 | 15254034 |
| A suggested new nomenclature for the isomers of isocitric acid. | VICKERY HB | 1962 Jun | 13925783 |
| The preparation of isocitric dehydrogenase from mammalian heart. | SIEBERT G, DUBUC J, WARNER RC, PLAUT GW | 1957 Jun | 13438885 |
| Partial purification and characterization of the isocitric dehydrogenase from Trypanosoma cruzi. | AGOSIN M, WEINBACH EC | 1956 Jul | 13363868 |
| Purification of the isocitric enzyme (triphosphopyridine nucleotide-linked isocitric dehydrogenase-oxalosuccinic carboxylase). | DIXON M, MOYLE J | 1956 Aug | 13355848 |
| Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism. | Ceccarelli C, Grodsky NB, Ariyaratne N, Colman RF, Bahnson BJ | 2002 Nov 8 | 12207025 |