EC number:1.1.1.44
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.44 |
|---|---|
| Description: | Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating). |
| Alternative Name: |
Phosphogluconic acid dehydrogenase. 6PGD. 6-phosphogluconic dehydrogenase. 6-phosphogluconic carboxylase. |
| Prosite: | PDOC00390; |
| PDB: |
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| Cath: | 1.10.1040.10; 1.20.5.320; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.44 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.44 |
| KEGG Enzyme Link: | KEGG1.1.1.44 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.44 |
| ExPASy Enzyme Link: | ExPASy1.1.1.44 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.44 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.44 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.44 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.44 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.44 |
| RHEA:10116 | 6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[C;H0;+0:10](-[OH;+0:11])-[CH;+0:12](-[*:13])-[CH;+0:14](-[*:15])-[OH;+0:16]>>[*:13]-[CH2;+0:12]-[C;H0;+0:14](-[*:15])=[O;H0;+0:16].[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10]=[O;H0;+0:11] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA. | Yoshida Y, Nakano Y, Yamashita Y, Koga T | 1997 Jan 3 | 9020051 |
| Purification and properties of glucose-6-phosphate dehydrogenase (NADP+/NAD+) and 6-phosphogluconate dehydrogenase (NADP+/NAD+) from methanol-grown Pseudomonas C. | Ben-Bassat A, Goldberg I | 1980 Jan 11 | 7350909 |
| 6-phospho-D-gluconate dehydrogenase from Pseudomonas fluorescens. Properties and subunit structure. | Stournaras C, Maurer P, Kurz G | 1983 Feb 1 | 6402366 |
| Kinetic studies of Haemophilus influenzae 6-phosphogluconate dehydrogenase. | Yoon H, Anderson CD, Anderson BM | 1989 Jan 19 | 2783298 |
| Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism. | Chen YY, Ko TP, Chen WH, Lo LP, Lin CH, Wang AH | 2010 Jan | 19686854 |
| Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1. | He W, Wang Y, Liu W, Zhou CZ | 2007 Jun 14 | 17570834 |
| The Bacillus subtilis yqjI gene encodes the NADP+-dependent 6-P-gluconate dehydrogenase in the pentose phosphate pathway. | Zamboni N, Fischer E, Laudert D, Aymerich S, Hohmann HP, Sauer U | 2004 Jul | 15231785 |
| Identification of an arginine residue in the dual coenzyme-specific glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides that plays a key role in binding NADP+ but not NAD+. | Levy HR, Vought VE, Yin X, Adams MJ | 1996 Feb 1 | 8579362 |