EC number:1.1.1.53
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.53 | ||
|---|---|---|---|
| Description: | 3-alpha(or 20-beta)-hydroxysteroid dehydrogenase. | ||
| Alternative Name: |
Cortisone reductase. (R)-20-hydroxysteroid dehydrogenase. | ||
| Prosite: | PDOC00060; | ||
| PDB: |
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| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.53 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.53 |
| KEGG Enzyme Link: | KEGG1.1.1.53 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.53 |
| ExPASy Enzyme Link: | ExPASy1.1.1.53 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.53 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.53 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.53 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.53 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.53 |
| RHEA:42004 | 5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| cDNA cloning and characterization of a cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase. | Chai X, Zhai Y, Napoli JL | 1997 Dec 26 | 9407098 |
| Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. | Steckelbroeck S, Jin Y, Gopishetty S, Oyesanmi B, Penning TM | 2004 Mar 12 | 14672942 |
| Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase. | Chetyrkin SV, Hu J, Gough WH, Dumaual N, Kedishvili NY | 2001 Feb 1 | 11360992 |
| Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties. | Chetyrkin SV, Belyaeva OV, Gough WH, Kedishvili NY | 2001 Jun 22 | 11294878 |
| Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD. | Shafqat N, Marschall HU, Filling C, Nordling E, Wu XQ, Björk L, Thyberg J, Mårtensson E, Salim S, Jörnvall H, Oppermann U | 2003 Nov 15 | 12917011 |
| Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. | Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K | 2000 Oct 1 | 10998348 |
| Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue. | Wang J, Chai X, Eriksson U, Napoli JL | 1999 Feb 15 | 9931293 |
| cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids. | Gough WH, VanOoteghem S, Sint T, Kedishvili NY | 1998 Jul 31 | 9677409 |
| RHEA:22400 | androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Comparison of the 3alpha-and 20beta-hydroxysteroid dehydrogenase activities of the cortisone reductase of Streptomyces hydrogenans. | Edwards CA, Orr JC | 1978 Oct 17 | 718844 |
| Study of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with an enzyme-generated affinity alkylator: dual enzyme activity at a single active site. | Strickler RC, Covey DF, Tobias B | 1980 Oct 28 | 6936053 |
| Bifunctional enzyme activity at the same active site: study of 3 alpha and 20 beta activity by affinity alkylation of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids. | Sweet F, Samant BR | 1980 Mar 4 | 6928375 |
| [20 beta-Hydroxysteroid dehydrogenase. 2. Preparation and crystallization]. | HUEBENER HJ, SAHRHOLZ FG | 1960 | 14403761 |
| [20 beta-Hydroxysteroid dehydrogenase, a new crystalline enzyme]. | HUEBENER HJ, SAHRHOLZ FG, SCHMIDT-THOME J, NESEMANN G, JUNK R | 1959 Sep | 14403760 |