EC number:1.1.1.60
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.60 |
|---|---|
| Description: | 2-hydroxy-3-oxopropionate reductase. |
| Alternative Name: |
Tartronate semialdehyde reductase. |
| Cath: | 1.10.1040.10; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.60 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.60 |
| KEGG Enzyme Link: | KEGG1.1.1.60 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.60 |
| ExPASy Enzyme Link: | ExPASy1.1.1.60 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.60 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.60 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.60 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.60 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.60 |
| RHEA:18845 | D-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli. | Hubbard BK, Koch M, Palmer DR, Babbitt PC, Gerlt JA | 1998 Oct 13 | 9772162 |
| RHEA:18841 | D-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli. | Hubbard BK, Koch M, Palmer DR, Babbitt PC, Gerlt JA | 1998 Oct 13 | 9772162 |
| The metabolism of C2 compounds in micro-organisms. 7. Preparation and properties of crystalline tartronic semialdehyde reductase. | GOTTO AM, KORNBERG HL | 1961 Nov | 13900766 |