Enzyme

Download
EC Tree
     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.64
Description:Testosterone 17-beta-dehydrogenase (NADP(+)).
Alternative Name: 17-ketoreductase.
Cath: 3.20.20.10; 3.20.20.100;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.64
BRENDA Enzyme Link: BRENDA 1.1.1.64
KEGG Enzyme Link: KEGG1.1.1.64
BioCyc Enzyme Link: BioCyc 1.1.1.64
ExPASy Enzyme Link: ExPASy1.1.1.64
EC2PDB Enzyme Link: EC2PDB 1.1.1.64
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.64
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.64
IntEnz Enzyme Link: IntEnz 1.1.1.64
MEDLINE Enzyme Link: MEDLINE 1.1.1.64
MSA:

1.1.1.64;

Phylogenetic Tree:

1.1.1.64;

Uniprot:
M-CSA:
RHEA:14981 NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat.Nokelainen P, Peltoketo H, Vihko R, Vihko P1998 Jul9658408
Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3.Geissler WM, Davis DL, Wu L, Bradshaw KD, Patel S, Mendonca BB, Elliston KO, Wilson JD, Russell DW, Andersson S1994 May8075637
Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates.Weber S, Salabei JK, Möller G, Kremmer E, Bhatnagar A, Adamski J, Barski OA2015 Mar 625577493
Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.Byrns MC, Duan L, Lee SH, Blair IA, Penning TM2010 Feb 1520036328
Androgen metabolism via 17beta-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme.Mindnich R, Haller F, Halbach F, Moeller G, Hrabé de Angelis M, Adamski J2005 Oct16216911
Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K2000 Oct 110998348