EC number:1.1.1.78

Enzyme

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EC Tree
     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.78
Description:Methylglyoxal reductase (NADH).
Alternative Name: Methylglyoxal reductase (NADH-dependent).
Methylglyoxal reductase.
D-lactaldehyde dehydrogenase.
Prosite: PDOC00061;
PDB:
PDBScop
Cath: 3.20.20.10; 3.20.20.100; 3.40.50.720;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.78
BRENDA Enzyme Link: BRENDA 1.1.1.78
KEGG Enzyme Link: KEGG1.1.1.78
BioCyc Enzyme Link: BioCyc 1.1.1.78
ExPASy Enzyme Link: ExPASy1.1.1.78
EC2PDB Enzyme Link: EC2PDB 1.1.1.78
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.78
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.78
IntEnz Enzyme Link: IntEnz 1.1.1.78
MEDLINE Enzyme Link: MEDLINE 1.1.1.78

EC number:1.1.1.78

MSA:

1.1.1.78;
Phylogenetic Tree:

1.1.1.78;
Uniprot:
M-CSA:
RHEA:24528 (R)-lactaldehyde + NAD(+) = H(+) + methylglyoxal + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Purification and partial characterization of a methylglyoxal reductase from goat liver.Ray M, Ray S1984 Nov 66386056
THE METABOLISM OF LACTALDEHYDE. VII. THE OXIDATION OF D-LACTALDEHYDE IN RAT LIVER.TING SM, MILLER ON, SELLINGER OZ1965 Mar 814323585