EC number:1.1.1.87

Enzyme

Download
EC Tree
     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.87
Description:Homoisocitrate dehydrogenase.
Alternative Name: Homoisocitric dehydrogenase.
3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating).
3-carboxy-2-hydroxyadipate dehydrogenase.
2-hydroxy-3-carboxyadipate dehydrogenase.
(decarboxylating).
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase
Prosite: PDOC00389;
PDB:
PDBScop
Cath: 3.40.718.10;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.87
BRENDA Enzyme Link: BRENDA 1.1.1.87
KEGG Enzyme Link: KEGG1.1.1.87
BioCyc Enzyme Link: BioCyc 1.1.1.87
ExPASy Enzyme Link: ExPASy1.1.1.87
EC2PDB Enzyme Link: EC2PDB 1.1.1.87
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.87
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.87
IntEnz Enzyme Link: IntEnz 1.1.1.87
MEDLINE Enzyme Link: MEDLINE 1.1.1.87

EC number:1.1.1.87

MSA:

1.1.1.87;
Phylogenetic Tree:

1.1.1.87;
Uniprot:
M-CSA:
RHEA:11900 (1R,2S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[C;H0;+0:3](=[*:4])-[OH;+0:5])-[CH;+0:6](-[*:7])-[OH;+0:8].[*:9]-[n+;H0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[c;H0;+0:14](-[*:15]):[cH;+0:16]:1>>[*:1]-[CH2;+0:2]-[C;H0;+0:6](-[*:7])=[O;H0;+0:8].[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[CH;+0:12]-[CH2;+0:13]-[C;H0;+0:14](-[*:15])=[CH;+0:16]-1.[*:4]=[C;H0;+0:3]=[O;H0;+0:5]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.Miyazaki K2005 May 2715845397
Lysine biosynthesis and metabolism in fungi.Zabriskie TM, Jackson MD2000 Feb10714900