EC number:1.1.1.88
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.88 | ||
|---|---|---|---|
| Description: | Hydroxymethylglutaryl-CoA reductase. | ||
| Alternative Name: |
Hydroxymethylglutaryl coenzyme A reductase. HMG-CoA reductase. Beta-hydroxy-beta-methylglutaryl coenzyme A reductase. Beta-hydroxy-beta-methylglutaryl CoA-reductase. 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | ||
| Prosite: | PDOC00064; | ||
| PDB: |
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| Cath: | 1.10.8.660; 3.30.70.420; 3.90.770.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.88 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.88 |
| KEGG Enzyme Link: | KEGG1.1.1.88 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.88 |
| ExPASy Enzyme Link: | ExPASy1.1.1.88 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.88 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.88 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.88 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.88 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.88 |
| RHEA:14833 | (R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[SH;+0:5].[*:6]-[c;H0;+0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[n+;H0:11](-[*:12]):[cH;+0:13]:1.[*:14]-[n+;H0:15]1:[cH;+0:16]:[c;H0;+0:17](-[*:18]):[cH;+0:19]:[cH;+0:20]:[cH;+0:21]:1>>[*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[S;H0;+0:5]-[*:4].[*:6]-[C;H0;+0:7]1=[CH;+0:13]-[N;H0;+0:11](-[*:12])-[CH;+0:10]=[CH;+0:9]-[CH2;+0:8]-1.[*:14]-[N;H0;+0:15]1-[CH;+0:16]=[C;H0;+0:17](-[*:18])-[CH2;+0:19]-[CH;+0:20]=[CH;+0:21]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Active form of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Rogers KS, Rodwell VW, Geiger P | 1997 Jun | 9232206 |
| Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii. | Hedl M, Rodwell VW | 2004 Jun | 15152097 |