EC number:1.1.1.93
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.93 |
|---|---|
| Description: | Tartrate dehydrogenase. |
| Alternative Name: |
Mesotartrate dehydrogenase. |
| Cath: | 3.40.718.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.93 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.93 |
| KEGG Enzyme Link: | KEGG1.1.1.93 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.93 |
| ExPASy Enzyme Link: | ExPASy1.1.1.93 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.93 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.93 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.93 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.93 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.93 |
| RHEA:15209 | (2R,3R)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of the multiple catalytic activities of tartrate dehydrogenase. | Tipton PA, Peisach J | 1990 Feb 20 | 2184888 |
| Structural characterization of tartrate dehydrogenase: a versatile enzyme catalyzing multiple reactions. | Malik R, Viola RE | 2010 Jun | 20516620 |
| An isothermal titration calorimetry study of the binding of substrates and ligands to the tartrate dehydrogenase from Pseudomonas putida reveals half-of-the-sites reactivity. | Karsten WE, Cook PF | 2006 Jul 25 | 16846243 |
| RHEA:16457 | (2R,3S)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of the multiple catalytic activities of tartrate dehydrogenase. | Tipton PA, Peisach J | 1990 Feb 20 | 2184888 |
| Structural characterization of tartrate dehydrogenase: a versatile enzyme catalyzing multiple reactions. | Malik R, Viola RE | 2010 Jun | 20516620 |
| An isothermal titration calorimetry study of the binding of substrates and ligands to the tartrate dehydrogenase from Pseudomonas putida reveals half-of-the-sites reactivity. | Karsten WE, Cook PF | 2006 Jul 25 | 16846243 |
| RHEA:18853 | NAD(+) + tartrate = 2-hydroxy-3-oxosuccinate + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of the multiple catalytic activities of tartrate dehydrogenase. | Tipton PA, Peisach J | 1990 Feb 20 | 2184888 |
| Structural characterization of tartrate dehydrogenase: a versatile enzyme catalyzing multiple reactions. | Malik R, Viola RE | 2010 Jun | 20516620 |
| An isothermal titration calorimetry study of the binding of substrates and ligands to the tartrate dehydrogenase from Pseudomonas putida reveals half-of-the-sites reactivity. | Karsten WE, Cook PF | 2006 Jul 25 | 16846243 |