EC number:1.1.1.94
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.94 | ||
|---|---|---|---|
| Description: | Glycerol-3-phosphate dehydrogenase (NAD(P)(+)). | ||
| Alternative Name: |
L-glycerol-3-phosphate:NAD(P) oxidoreductase. (phosphate)). Glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide Glycerol 3-phosphate dehydrogenase (NADP). Glycerol 3-phosphate dehydrogenase (NAD(P)). | ||
| Prosite: | PDOC00740; | ||
| PDB: |
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| Cath: | 1.10.1040.10; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.94 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.94 |
| KEGG Enzyme Link: | KEGG1.1.1.94 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.94 |
| ExPASy Enzyme Link: | ExPASy1.1.1.94 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.94 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.94 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.94 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.94 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.94 |
| RHEA:11096 | NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biosynthesis in Escherichia coli of sn-glycerol-3-phosphate, a precursor of phospholipid. Further kinetic characterization of wild type and feedback-resistant forms of the biosynthetic sn-glycerol-3-phosphate dehydrogenase. | Edgar JR, Bell RM | 1980 Apr 25 | 6767719 |
| Purification and regulatory properties of the biosynthetic L-glycerol 3-phosphate dehydrogenase from Escherichia coli. | Kito M, Pizer LI | 1969 Jun 25 | 4389388 |
| Biosynthesis in Escherichia coli fo sn-glycerol 3-phosphate, a precursor of phospholipid. | Edgar JR, Bell RM | 1978 Sep 25 | 355254 |
| Biosynthesis in Escherichia coli of sn-glycerol 3-phosphate, a precursor of phospholipid. Kinetic characterization of wild type and feedback-resistant forms of the biosynthetic sn-glycerol-3-phosphate dehydrogenase. | Edgar JR, Bell RM | 1978 Sep 25 | 28326 |
| Structural and functional analysis of the gpsA gene product of Archaeoglobus fulgidus: a glycerol-3-phosphate dehydrogenase with an unusual NADP+ preference. | Sakasegawa S, Hagemeier CH, Thauer RK, Essen LO, Shima S | 2004 Dec | 15557260 |
| RHEA:11092 | NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning, sequencing and expression of a cDNA encoding a human liver NAD-dependent alpha-glycerol-3-phosphate dehydrogenase. | Menaya J, González-Manchón C, Parrilla R, Ayuso MS | 1995 May 17 | 7772607 |
| Comparative structural properties of honeybee and rabbit alpha-glycerophosphate dehydrogenases. | Brosemer RW, Kuhn RW | 1969 May | 4307630 |
| Biochemical and Molecular-Genetic Characterization of SFD1's Involvement in Lipid Metabolism and Defense Signaling. | Lorenc-Kukula K, Chaturvedi R, Roth M, Welti R, Shah J | 2012 | 22645576 |
| Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1). | Ou X, Ji C, Han X, Zhao X, Li X, Mao Y, Wong LL, Bartlam M, Rao Z | 2006 Mar 31 | 16460752 |
| Structural and functional analysis of the gpsA gene product of Archaeoglobus fulgidus: a glycerol-3-phosphate dehydrogenase with an unusual NADP+ preference. | Sakasegawa S, Hagemeier CH, Thauer RK, Essen LO, Shima S | 2004 Dec | 15557260 |
| Oleic acid levels regulated by glycerolipid metabolism modulate defense gene expression in Arabidopsis. | Kachroo A, Venugopal SC, Lapchyk L, Falcone D, Hildebrand D, Kachroo P | 2004 Apr 6 | 15044700 |
| Purification and characterization of glycerol-3-phosphate dehydrogenase of Saccharomyces cerevisiae. | Albertyn J, van Tonder A, Prior BA | 1992 Aug 17 | 1499720 |
| The Arabidopsis thaliana dihydroxyacetone phosphate reductase gene SUPPRESSSOR OF FATTY ACID DESATURASE DEFICIENCY1 is required for glycerolipid metabolism and for the activation of systemic acquired resistance. | Nandi A, Welti R, Shah J | 2004 Feb | 14729910 |