EC number:1.1.1.n11
| ID: | 1.1.1.n11 |
|---|---|
| Description: | Succinic semialdehyde reductase. |
| Cath: | 1.10.1040.10; 3.20.20.10; 3.20.20.100; 3.40.50.720; |
3D structure
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| RHEA:26381 | 4-hydroxybutanoate + NADP(+) = H(+) + NADPH + succinate semialdehyde |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification from human brain and some properties of two NADPH-linked aldehyde reductases which reduce succinic semialdehyde to 4-hydroxybutyrate. | Cash CD, Maitre M, Mandel P | 1979 Dec | 45199 |
| Malonic semialdehyde reductase, succinic semialdehyde reductase, and succinyl-coenzyme A reductase from Metallosphaera sedula: enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in Sulfolobales. | Kockelkorn D, Fuchs G | 2009 Oct | 19684143 |
| Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity. | Zhu X, Lapthorn AJ, Ellis EM | 2006 Feb 14 | 16460003 |
| Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. | O'connor T, Ireland LS, Harrison DJ, Hayes JD | 1999 Oct 15 | 10510318 |