EC number:1.1.2.7
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.2 With a cytochrome as acceptor |
| ID: | 1.1.2.7 |
|---|---|
| Description: | Methanol dehydrogenase (cytochrome c). |
| Alternative Name: |
Methanol dehydrogenase. MDH. |
| Cath: | 4.10.160.10; 2.140.10.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.2.7 |
| BRENDA Enzyme Link: | BRENDA 1.1.2.7 |
| KEGG Enzyme Link: | KEGG1.1.2.7 |
| BioCyc Enzyme Link: | BioCyc 1.1.2.7 |
| ExPASy Enzyme Link: | ExPASy1.1.2.7 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.2.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.2.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.2.7 |
| IntEnz Enzyme Link: | IntEnz 1.1.2.7 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.2.7 |
| RHEA:51008 | 2 [Fe(III)cytochrome cL] + methanol = 2 [Fe(II)cytochrome cL] + formaldehyde + 2 H(+) |
| RULE(radius=1) | [CH3;+0:1]-[OH;+0:2].[Fe+3;H0:3].[Fe+3;H0:4]>>[CH2;+0:1]=[O;H0;+0:2].[Fe+2;H0:3].[Fe+2;H0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Detailed active site configuration of a new crystal form of methanol dehydrogenase from Methylophilus W3A1 at 1.9 A resolution. | Xia ZX, He YN, Dai WW, White SA, Boyd GD, Mathews FS | 1999 Jan 26 | 9930981 |
| The active site of methanol dehydrogenase contains a disulphide bridge between adjacent cysteine residues. | Blake CC, Ghosh M, Harlos K, Avezoux A, Anthony C | 1994 Feb | 7656012 |
| Structure and activity of the prosthetic group of methanol dehydrogenase. | Duine JA, Frank J, Verwiel PE | 1980 | 6250827 |
| The microbial oxidation of methanol. The prosthetic group of the alcohol dehydrogenase of Pseudomonas sp. M27: a new oxidoreductase prosthetic group. | Anthony C, Zatman LJ | 1967 Sep | 6049934 |
| The microbial oxidation of methanol. 2. The methanol-oxidizing enzyme of Pseudomonas sp. M 27. | Anthony C, Zatman LJ | 1964 Sep | 4378696 |
| The atomic resolution structure of methanol dehydrogenase from Methylobacterium extorquens. | Williams PA, Coates L, Mohammed F, Gill R, Erskine PT, Coker A, Wood SP, Anthony C, Cooper JB | 2005 Jan | 15608378 |
| The interaction of methanol dehydrogenase and its electron acceptor, cytochrome cL in methylotrophic bacteria. | Cox JM, Day DJ, Anthony C | 1992 Feb 13 | 1311606 |
| The structure and mechanism of methanol dehydrogenase. | Anthony C, Williams P | 2003 Apr 11 | 12686102 |
| Site-directed mutagenesis and X-ray crystallography of the PQQ-containing quinoprotein methanol dehydrogenase and its electron acceptor, cytochrome c(L). | Afolabi PR, Mohammed F, Amaratunga K, Majekodunmi O, Dales SL, Gill R, Thompson D, Cooper JB, Wood SP, Goodwin PM, Anthony C | 2001 Aug 21 | 11502173 |
| RHEA:51004 | 2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H(+) |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[Fe+3;H0:4].[Fe+3;H0:5]>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[Fe+2;H0:4].[Fe+2;H0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Detailed active site configuration of a new crystal form of methanol dehydrogenase from Methylophilus W3A1 at 1.9 A resolution. | Xia ZX, He YN, Dai WW, White SA, Boyd GD, Mathews FS | 1999 Jan 26 | 9930981 |
| The active site of methanol dehydrogenase contains a disulphide bridge between adjacent cysteine residues. | Blake CC, Ghosh M, Harlos K, Avezoux A, Anthony C | 1994 Feb | 7656012 |
| Structure and activity of the prosthetic group of methanol dehydrogenase. | Duine JA, Frank J, Verwiel PE | 1980 | 6250827 |
| The microbial oxidation of methanol. The prosthetic group of the alcohol dehydrogenase of Pseudomonas sp. M27: a new oxidoreductase prosthetic group. | Anthony C, Zatman LJ | 1967 Sep | 6049934 |
| The microbial oxidation of methanol. 2. The methanol-oxidizing enzyme of Pseudomonas sp. M 27. | Anthony C, Zatman LJ | 1964 Sep | 4378696 |
| The atomic resolution structure of methanol dehydrogenase from Methylobacterium extorquens. | Williams PA, Coates L, Mohammed F, Gill R, Erskine PT, Coker A, Wood SP, Anthony C, Cooper JB | 2005 Jan | 15608378 |
| The interaction of methanol dehydrogenase and its electron acceptor, cytochrome cL in methylotrophic bacteria. | Cox JM, Day DJ, Anthony C | 1992 Feb 13 | 1311606 |
| The structure and mechanism of methanol dehydrogenase. | Anthony C, Williams P | 2003 Apr 11 | 12686102 |
| Site-directed mutagenesis and X-ray crystallography of the PQQ-containing quinoprotein methanol dehydrogenase and its electron acceptor, cytochrome c(L). | Afolabi PR, Mohammed F, Amaratunga K, Majekodunmi O, Dales SL, Gill R, Thompson D, Cooper JB, Wood SP, Goodwin PM, Anthony C | 2001 Aug 21 | 11502173 |