EC number:1.1.3.15
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.3 With oxygen as acceptor |
| ID: | 1.1.3.15 | ||
|---|---|---|---|
| Description: | (S)-2-hydroxy-acid oxidase. | ||
| Alternative Name: |
Hydroxy-acid oxidase B. Hydroxy-acid oxidase A. Glycolate oxidase. | ||
| Prosite: | PDOC00482; | ||
| PDB: |
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| Cath: | 3.20.20.70; 3.30.9.10; 3.50.50.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.3.15 |
| BRENDA Enzyme Link: | BRENDA 1.1.3.15 |
| KEGG Enzyme Link: | KEGG1.1.3.15 |
| BioCyc Enzyme Link: | BioCyc 1.1.3.15 |
| ExPASy Enzyme Link: | ExPASy1.1.3.15 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.3.15 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.3.15 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.3.15 |
| IntEnz Enzyme Link: | IntEnz 1.1.3.15 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.3.15 |
| RHEA:25311 | glycolate + O2 = glyoxylate + H2O2 |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[O;H0;+0:4]=[O;H0;+0:5]>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[OH;+0:4]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
| RHEA:16789 | a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2 |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[O;H0;+0:5]=[O;H0;+0:6]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[OH;+0:5]-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of glycolic acid oxidase from pig liver. | Schuman M, Massey V | 1971 Mar 10 | 5569122 |
| Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design. | Murray MS, Holmes RP, Lowther WT | 2008 Feb 26 | 18215067 |
| Oxalate accumulation and regulation is independent of glycolate oxidase in rice leaves. | Xu HW, Ji XM, He ZH, Shi WP, Zhu GH, Niu JK, Li BS, Peng XX | 2006 | 16595582 |
| Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. | Jones JM, Morrell JC, Gould SJ | 2000 Apr 28 | 10777549 |