EC number:1.1.3.8
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.3 With oxygen as acceptor |
| ID: | 1.1.3.8 |
|---|---|
| Description: | L-gulonolactone oxidase. |
| Alternative Name: |
L-gulono-gamma-lactone oxidase. GLO. |
| Prosite: | PDOC00674; |
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.3.8 |
| BRENDA Enzyme Link: | BRENDA 1.1.3.8 |
| KEGG Enzyme Link: | KEGG1.1.3.8 |
| BioCyc Enzyme Link: | BioCyc 1.1.3.8 |
| ExPASy Enzyme Link: | ExPASy1.1.3.8 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.3.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.3.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.3.8 |
| IntEnz Enzyme Link: | IntEnz 1.1.3.8 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.3.8 |
| RHEA:32363 | L-gulono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH;+0:4](-[*:5])-[*:6].[O;H0;+0:7]=[O;H0;+0:8]>>[*:1]-[C;H0;+0:2](-[*:3])=[C;H0;+0:4](-[*:5])-[*:6].[OH;+0:7]-[OH;+0:8] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man. | Nishikimi M, Fukuyama R, Minoshima S, Shimizu N, Yagi K | 1994 May 6 | 8175804 |
| Purification and characterization of L-gulonolactone oxidase from chicken kidney microsomes. | Kiuchi K, Nishikimi M, Yagi K | 1982 Sep 28 | 7138847 |
| The contribution of Arabidopsis homologs of L-gulono-1,4-lactone oxidase to the biosynthesis of ascorbic acid. | Maruta T, Ichikawa Y, Mieda T, Takeda T, Tamoi M, Yabuta Y, Ishikawa T, Shigeoka S | 2010 | 20622436 |
| Functional rescue of vitamin C synthesis deficiency in human cells using adenoviral-based expression of murine l-gulono-gamma-lactone oxidase. | Ha MN, Graham FL, D'Souza CK, Muller WJ, Igdoura SA, Schellhorn HE | 2004 Mar | 14962674 |
| Synthesis of L-ascorbic acid in rat-liver homogenates. Conversion of L-gulono- and L-galactono-gamma-lactone and the respective acids into L-ascorbic acid. | ISHERWOOD FA, MAPSON LW, CHEN YT | 1960 Jul | 14405898 |
| Induction and peroxisomal appearance of gulonolactone oxidase upon clofibrate treatment in mouse liver. | Braun L, Mile V, Schaff Z, Csala M, Kardon T, Mandl J, Bánhegyi G | 1999 Sep 24 | 10570940 |