EC number:1.1.5.12
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.5 With a quinone or similar compound as acceptor |
| ID: | 1.1.5.12 |
|---|---|
| Description: | D-lactate dehydrogenase (quinone). |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.5.12 |
| BRENDA Enzyme Link: | BRENDA 1.1.5.12 |
| KEGG Enzyme Link: | KEGG1.1.5.12 |
| BioCyc Enzyme Link: | BioCyc 1.1.5.12 |
| ExPASy Enzyme Link: | ExPASy1.1.5.12 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.5.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.5.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.5.12 |
| IntEnz Enzyme Link: | IntEnz 1.1.5.12 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.5.12 |
| RHEA:51468 | (R)-lactate + a quinone = a quinol + pyruvate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[C;H0;+0:3](-[*:4])-[C;H0;+0:5](=[O;H0;+0:6])-[C;H0;+0:7](-[*:8])=[C;H0;+0:9](-[*:10])-[C;H0;+0:11]-1=[O;H0;+0:12].[*:13]-[CH;+0:14](-[*:15])-[OH;+0:16]>>[*:13]-[C;H0;+0:14](-[*:15])=[O;H0;+0:16].[*:1]-[c;H0;+0:2]1:[c;H0;+0:11](-[OH;+0:12]):[c;H0;+0:9](-[*:10]):[c;H0;+0:7](-[*:8]):[c;H0;+0:5](-[OH;+0:6]):[c;H0;+0:3]:1-[*:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Membrane D-lactate dehydrogenase from Escherichia coli. Purification and properties. | Futai M | 1973 Jun 19 | 4575624 |
| D-lactate oxidation and generation of the proton electrochemical gradient in membrane vesicles from Escherichia coli GR19N and in proteoliposomes reconstituted with purified D-lactate dehydrogenase and cytochrome o oxidase. | Matsushita K, Kaback HR | 1986 May 6 | 3013300 |
| Site-specific incorporation of 5-fluorotryptophan as a probe of the structure and function of the membrane-bound D-lactate dehydrogenase of Escherichia coli: a 19F nuclear magnetic resonance study. | Peersen OB, Pratt EA, Truong HT, Ho C, Rule GS | 1990 Apr 3 | 2185834 |
| The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme. | Dym O, Pratt EA, Ho C, Eisenberg D | 2000 Aug 15 | 10944213 |