EC number:1.1.99.2
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.99 With unknown physiological acceptors |
| ID: | 1.1.99.2 |
|---|---|
| Description: | L-2-hydroxyglutarate dehydrogenase. |
| Alternative Name: |
L-alpha-hydroxyglutarate dehydrogenase. Hydroxyglutaric dehydrogenase. Alpha-ketoglutarate reductase. Alpha-hydroxyglutarate oxidoreductase. Alpha-hydroxyglutarate dehydrogenase. |
| Cath: | 3.30.360.10; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.99.2 |
| BRENDA Enzyme Link: | BRENDA 1.1.99.2 |
| KEGG Enzyme Link: | KEGG1.1.99.2 |
| BioCyc Enzyme Link: | BioCyc 1.1.99.2 |
| ExPASy Enzyme Link: | ExPASy1.1.99.2 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.99.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.99.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.99.2 |
| IntEnz Enzyme Link: | IntEnz 1.1.99.2 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.99.2 |
| RHEA:21252 | (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2 |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways. | Engqvist M, Drincovich MF, Flügge UI, Maurino VG | 2009 Sep 11 | 19586914 |
| The oxidation of l(-)alpha-hydroxyglutaric acid in animal tissues. | Weil-Malherbe H | 1937 Nov | 16746551 |
| The gene mutated in l-2-hydroxyglutaric aciduria encodes l-2-hydroxyglutarate dehydrogenase. | Rzem R, Van Schaftingen E, Veiga-da-Cunha M | 2006 Jan | 16005139 |