EC number:1.1.99.24
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.99 With unknown physiological acceptors |
| ID: | 1.1.99.24 |
|---|---|
| Description: | Hydroxyacid-oxoacid transhydrogenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.99.24 |
| BRENDA Enzyme Link: | BRENDA 1.1.99.24 |
| KEGG Enzyme Link: | KEGG1.1.99.24 |
| BioCyc Enzyme Link: | BioCyc 1.1.99.24 |
| ExPASy Enzyme Link: | ExPASy1.1.99.24 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.99.24 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.99.24 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.99.24 |
| IntEnz Enzyme Link: | IntEnz 1.1.99.24 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.99.24 |
EC number:1.1.99.24
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:24734 | 2-oxoglutarate + 4-hydroxybutanoate = (R)-2-hydroxyglutarate + succinate semialdehyde |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[CH2;+0:6]-[OH;+0:7]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[CH;+0:6]=[O;H0;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria. | Kaufman EE, Nelson T, Fales HM, Levin DM | 1988 Nov 15 | 3182820 |
| Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate. | Kardon T, Noël G, Vertommen D, Schaftingen EV | 2006 Apr 17 | 16616524 |
| Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. | Struys EA, Verhoeven NM, Ten Brink HJ, Wickenhagen WV, Gibson KM, Jakobs C | 2005 | 16435184 |
| RHEA:23048 | (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[CH;+0:6](-[*:7])-[OH;+0:8]>>[*:5]-[C;H0;+0:6](-[*:7])=[O;H0;+0:8].[*:1]-[CH;+0:2](-[*:3])-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria. | Kaufman EE, Nelson T, Fales HM, Levin DM | 1988 Nov 15 | 3182820 |
| Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. | Struys EA, Verhoeven NM, Ten Brink HJ, Wickenhagen WV, Gibson KM, Jakobs C | 2005 | 16435184 |