EC number:1.1.99.36
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.99 With unknown physiological acceptors |
| ID: | 1.1.99.36 |
|---|---|
| Description: | Alcohol dehydrogenase (nicotinoprotein). |
| Alternative Name: |
Nicotinoprotein alcohol dehydrogenase. NDMA-dependent alcohol dehydrogenase. |
| Cath: | 3.40.50.720; 3.90.180.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.99.36 |
| BRENDA Enzyme Link: | BRENDA 1.1.99.36 |
| KEGG Enzyme Link: | KEGG1.1.99.36 |
| BioCyc Enzyme Link: | BioCyc 1.1.99.36 |
| ExPASy Enzyme Link: | ExPASy1.1.99.36 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.99.36 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.99.36 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.99.36 |
| IntEnz Enzyme Link: | IntEnz 1.1.99.36 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.99.36 |
EC number:1.1.99.36
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:33567 | A + ethanol = acetaldehyde + AH2 |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3]>>[*:1]-[CH;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Nicotinoprotein [NAD(P)-containing] alcohol/aldehyde oxidoreductases. Purification and characterization of a novel type from Amycolatopsis methanolica. | Van Ophem PW, Van Beeumen J, Duine JA | 1993 Mar 15 | 8385013 |
| Inhibition of nicotinoprotein (NAD+-containing) alcohol dehydrogenase by trans-4-(N,N-dimethylamino)-cinnamaldehyde binding to the active site. | Piersma SR, Norin A, de Vries S, Jörnvall H, Duine JA | 2003 Jul | 14690248 |
| RHEA:27538 | ethanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde |
| RULE(radius=1) | [C;+0:2]-[OH;+0:3].[*:4]-[N;H0;+0:5]=[O;H0;+0:6]>>[C;+0:2]=[O;H0;+0:3].[*:4]-[NH;+0:5]-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Optical spectroscopy of nicotinoprotein alcohol dehydrogenase from Amycolatopsis methanolica: a comparison with horse liver alcohol dehydrogenase and UDP-galactose epimerase. | Piersma SR, Visser AJ, de Vries S, Duine JA | 1998 Mar 3 | 9485460 |
| Inhibition of nicotinoprotein (NAD+-containing) alcohol dehydrogenase by trans-4-(N,N-dimethylamino)-cinnamaldehyde binding to the active site. | Piersma SR, Norin A, de Vries S, Jörnvall H, Duine JA | 2003 Jul | 14690248 |
| Nicotinoprotein (NAD+ -containing) alcohol dehydrogenase: structural relationships and functional interpretations. | Norin A, Piersma SR, Duine JA, Jörnvall H | 2003 May | 12827287 |